Selective demyelination of a sciatic nerve allograft after SARS-CoV-2 infection – Case report

Peripheral neurological complications are seen after SARS-CoV-2 infections. These are mostly immune-mediated such as Guillaine–Barré syndrome or chronic inflammatory demyelinating polyneuropathy. We present a 39-year-old man treated with a right sciatic nerve allotransplantation with subsequent clin...

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Bibliographic Details
Published in:Heliyon 2023-10, Vol.9 (10), p.e20624, Article e20624
Main Authors: Koszewicz, Magdalena, Kaminska, Dorota, Martynkiewicz, Jacek, Domanasiewicz, Adam, Gosk, Jerzy
Format: Article
Language:English
Subjects:
Case Report
Demyelination
Intravenous immunoglobulins
Nerve allograft
Nerve injury
SARS-CoV-2
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Summary:Peripheral neurological complications are seen after SARS-CoV-2 infections. These are mostly immune-mediated such as Guillaine–Barré syndrome or chronic inflammatory demyelinating polyneuropathy. We present a 39-year-old man treated with a right sciatic nerve allotransplantation with subsequent clinical and electrophysiological improvement within 30 months of observation. After SARS-CoV-2 infection, he developed clinical deterioration with selective sciatic nerve demyelination in a nerve conduction study. Nerve conduction velocity returned to previous values within six months of treatment. Intravenous immunoglobulins were used at standard dosage. The inflammatory immune process seemed to be a cause of peripheral demyelination isolated to a nerve allograft with good reaction for intravenous immunoglobulin treatment.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e20624