Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment

Despite the fact that nanocarriers as drug delivery systems overcome the limitation of chemotherapy, the leakage of encapsulated drugs during the delivery process to the target site can still cause toxic effects to healthy cells in other tissues and organs in the body. Controlling drug release at th...

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Bibliographic Details
Published in:Pharmaceutics 2019-11, Vol.11 (11), p.591
Main Authors: Le, Ngoc Thuy Trang, Nguyen, Thi Nhu Quynh, Cao, Van Du, Hoang, Duc Thuan, Ngo, Van Cuong, Hoang Thi, Thai Thanh
Format: Article
Language:English
Subjects:
Cancer therapies
cancer treatment
Cell division
Chemical reactions
Chemotherapy
drug delivery
Drug delivery systems
Drugs
Efficiency
Metastasis
multi-stimuli-responsiveness
Physiology
Polymers
Review
smart dendrimer
Tumors
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Summary:Despite the fact that nanocarriers as drug delivery systems overcome the limitation of chemotherapy, the leakage of encapsulated drugs during the delivery process to the target site can still cause toxic effects to healthy cells in other tissues and organs in the body. Controlling drug release at the target site, responding to stimuli that originated from internal changes within the body, as well as stimuli manipulated by external sources has recently received significant attention. Owning to the spherical shape and porous structure, dendrimer is utilized as a material for drug delivery. Moreover, the surface region of dendrimer has various moieties facilitating the surface functionalization to develop the desired material. Therefore, multi-stimuli-responsive dendrimers or 'smart' dendrimers that respond to more than two stimuli will be an inspired attempt to achieve the site-specific release and reduce as much as possible the side effects of the drug. The aim of this review was to delve much deeper into the recent progress of multi-stimuli-responsive dendrimers in the delivery of anticancer drugs in addition to the major potential challenges.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics11110591