Schlafens Can Put Viruses to Sleep

The Schlafen gene family encodes for proteins involved in various biological tasks, including cell proliferation, differentiation, and T cell development. Schlafens were initially discovered in mice, and have been studied in the context of cancer biology, as well as their role in protecting cells du...

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Bibliographic Details
Published in:Viruses 2022-02, Vol.14 (2), p.442
Main Authors: Kim, Eui Tae, Weitzman, Matthew D
Format: Article
Language:English
Subjects:
Animals
Binding sites
Cancer
Cell cycle
Cell Cycle Proteins - immunology
Cell differentiation
Cell proliferation
Chromosomes
DNA methylation
Endoribonucleases - immunology
Epigenetics
Fibroblasts
Gene expression
Genomes
Host-Pathogen Interactions - immunology
Humans
Immune Evasion
Immune system
Immunity, Innate
Innate immunity
Kinases
Lymphocytes T
Mammals
Mice
Proteins
restriction factor
Review
RNA viruses
Schlafen
SLFN
Transcription factors
virus
Virus Diseases - immunology
Viruses
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Summary:The Schlafen gene family encodes for proteins involved in various biological tasks, including cell proliferation, differentiation, and T cell development. Schlafens were initially discovered in mice, and have been studied in the context of cancer biology, as well as their role in protecting cells during viral infection. This protein family provides antiviral barriers via direct and indirect effects on virus infection. Schlafens can inhibit the replication of viruses with both RNA and DNA genomes. In this review, we summarize the cellular functions and the emerging relationship between Schlafens and innate immunity. We also discuss the functions and distinctions of this emerging family of proteins as host restriction factors against viral infection. Further research into Schlafen protein function will provide insight into their mechanisms that contribute to intrinsic and innate host immunity.
ISSN:1999-4915
1999-4915
DOI:10.3390/v14020442