Association between metabolic and hormonal profile, proinflammatory cytokines in saliva and gingival health in adolescent females with polycystic ovary syndrome

Research studies indicate that polycystic ovary syndrome (PCOS) may increase susceptibility to periodontal disease. The mechanisms that link both conditions are not entirely understood. Thus, the study aimed to investigate the impact of hormonal and metabolic disturbances on the gingival health and...

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Bibliographic Details
Published in:BMC oral health 2021-04, Vol.21 (1), p.193-193, Article 193
Main Authors: Wendland, Natalia, Opydo-Szymaczek, Justyna, Formanowicz, Dorota, Blacha, Anna, Jarząbek-Bielecka, Grażyna, Mizgier, Małgorzata
Format: Article
Language:English
Subjects:
Acne
Adolescent
Age
Androgens
Antibiotics
Blood tests
Body Mass Index
Cholesterol
Cytokines
Dental caries
Dentistry
Enzymes
Female
Gingiva
Gingival index
Gingivitis
Glucose
Gynecology
Hormones
Hospitals
Humans
Hygiene
Hyperandrogenism
Infertility
Inflammation
Insulin
Insulin Resistance
Interleukin 1
Interleukin 6
Laboratories
Lipid profile
Medical screening
Medicine
Menstruation
Metabolism
Obesity
Oral hygiene
Orthodontics
Periodontal diseases
Plaque index
Polycystic ovary syndrome
Polycystic Ovary Syndrome - complications
Saliva
Software
Teenagers
Testosterone
Tumor necrosis factor-α
Womens health
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Summary:Research studies indicate that polycystic ovary syndrome (PCOS) may increase susceptibility to periodontal disease. The mechanisms that link both conditions are not entirely understood. Thus, the study aimed to investigate the impact of hormonal and metabolic disturbances on the gingival health and salivary levels of tumor necrosis factor (TNF-α), interleukin 1β (IL1-β), and interleukin 6 (IL-6) in adolescent girls with PCOS. Thirty-one patients with PCOS and twenty-eight healthy age-mates (as the control group) were enrolled in the study. Individuals with PCOS underwent blood tests for the determination of hormonal and metabolic parameters. Saliva samples were collected to measure salivary testosterone and proinflammatory cytokines in both studied groups. Calibrated dentist assessed oral hygiene and gingival health of all subjects. Salivary testosterone was significantly higher in the study group (p = 0.0007). The groups did not differ significantly concerning periodontal parameters. Patients with PCOS revealed higher levels of salivary cytokines (p 
ISSN:1472-6831
1472-6831
DOI:10.1186/s12903-021-01553-9