Correlation of Visual Acuity and Outer Retinal Thickness in Myopic Atrophic Maculopathy: A Retrospective Review

Introduction Myopic atrophic maculopathy is prevalent among patients with pathologic myopia and frequently leads to relentless vision loss. Several grading systems were established to facilitate the understanding of myopic atrophic maculopathy. However, the anatomical details in different stages of...

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Bibliographic Details
Published in:Ophthalmology and therapy 2023-08, Vol.12 (4), p.1989-2003
Main Authors: Lee, Cheng-Yung, Hsia, Yun, Tsui, Mei-Chi, Wang, Shih-Wen, Huang, Chien-Jung, Ma, I-Hsin, Hung, Kuo-Chi, Chen, Muh-Shy, Ho, Tzyy-Chang
Format: Article
Language:English
Subjects:
Best-corrected visual acuity
Dome-shape macula
Internal Medicine
Medicine
Medicine & Public Health
Myopic atrophic maculopathy
Myopic choroidal neovascularization
Ophthalmology
Optical coherence tomography
Original Research
Pathologic myopia
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Summary:Introduction Myopic atrophic maculopathy is prevalent among patients with pathologic myopia and frequently leads to relentless vision loss. Several grading systems were established to facilitate the understanding of myopic atrophic maculopathy. However, the anatomical details in different stages of myopic maculopathy are so far not clearly elucidated. This study aims to investigate the visual acuity and retinal sublayer features in highly myopic eyes with varying severities of myopic atrophic maculopathy (MAM). Methods The clinical records of 111 consecutive patients (158 eyes) with high myopia (refractive error ≤ −6.0 D and axial length ≥ 26.0 mm) were reviewed. Fundus photography, optical coherence tomography (OCT), and best-corrected visual acuity (BCVA) were measured. MAM was graded according to the META-analysis for Pathologic Myopia (META-PM) classification system. Myopic choroidal neovascularization (mCNV) and dome-shaped macula (DSM) were also investigated. Results Among the 158 eyes, 18 (11%), 21(13%), 24 (15%), 25 (16%), 23 (15%), and 24 (15%) had tessellated fundus, diffuse chorioretinal atrophy, diffuse chorioretinal atrophy with DSM, patchy atrophy, patchy atrophy with DSM, and MAM with mCNV, respectively. A total of 23 (15%) eyes had macular atrophy without mCNV. Progressive thinning in the Henle’s fiber and outer nuclear layers, myoid and ellipsoid zone (MEZ), outer segment (OS), and interdigitation zone and retinal pigmented epithelium based on the severity of MAM ( p -value 
ISSN:2193-8245
2193-6528
DOI:10.1007/s40123-023-00710-3