Composite films based on Bi2Se3 nanosheets and carbon nanotubes with photothermal and photodynamic functions for synergistic treatment

• Published in: Materials & design 2023-09, Vol.233, p.112201, Article 112201
• Main Authors: Meng, Yu, Wang, Congcong, Song, Lijie, Su, Zewen, Jiang, Yaojun, Lian, Yanbang, Bai, Gongxun, Fan, Qingxia
• Format: Article
• Language: English
• Subjects: Bi2Se3; Carbon nanotubes; Nanocomposite; Photodynamic therapy; Photothermal therapy
• ISSN: 0264-1275
• DOI: 10.1016/j.matdes.2023.112201

Design of BPSC composite with dual photothermal and photodynamic functions for tumor therapy. [Display omitted] •Heterojunction composites were constructed with Bi2Se3 nanosheets and carbon nanotubes.•The efficient and safe tumor ablation has been realized with the composites with low laser power.•The composites can produce reactive oxygen species under near-infrared irradiation.•The composites exhibit good biocompatibility for photothermal and photodynamic therapy. The use of functional nanomaterials to realize tumor therapeutic therapy has received considerable attention. However, a single type of nanomaterial usually can only achieve one specific function, and may cause biosafety problems due to poor metabolism. In this work, we have designed a kind of nanocomposite film based on Bi2Se3 nanosheets and carbon nanotubes, which can achieve efficient photothermal conversion and reactive oxygen species generation under near-infrared laser irradiation. Moreover, the developed films showed good biocompatibility in vivo. The multifunctional films showed remarkable therapeutic effects under 808 nm excitation with 0.3 W/cm2, which avoiding the introduction of nano-reagents into the mice and excessive laser power damage. Our work will provide reference for the use of nanomaterials with heterojunctions in synergistic therapy strategies of photothermal and photodynamic therapy.