Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity

The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of glycosylated hemoglobin (HbA1c) in non-diabetic humans with obesity. 5-HTT availability was measured by using positron emission tomography (P...

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Bibliographic Details
Published in:Scientific reports 2020-12, Vol.10 (1), p.21383-21383, Article 21383
Main Authors: Grundmann, Rico, Rullmann, Michael, Luthardt, Julia, Zientek, Franziska, Becker, Georg-Alexander, Patt, Marianne, Hankir, Mohammed K., Blüher, Matthias, Sabri, Osama, Hesse, Swen
Format: Article
Language:English
Subjects:
692/308/2778
692/699/2743/393
Adult
Antidepressants
Appetite
Blood Glucose - metabolism
Diabetes
Diabetes mellitus
Emission measurements
Female
Glucose
Glycated Hemoglobin A - metabolism
Hemoglobin
Hippocampus
Hippocampus - metabolism
Humanities and Social Sciences
Humans
Hyperglycemia
Magnetic resonance imaging
Male
Middle Aged
Morphometry
multidisciplinary
Neuroimaging
Obesity
Obesity - metabolism
Plasma levels
Positron emission tomography
Radioactive tracers
Science
Science (multidisciplinary)
Serotonin
Serotonin Plasma Membrane Transport Proteins - metabolism
Serotonin transporter
Substantia grisea
Young Adult
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Summary:The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of glycosylated hemoglobin (HbA1c) in non-diabetic humans with obesity. 5-HTT availability was measured by using positron emission tomography (PET) imaging with the 5-HTT selective radiotracer [ 11 C]DASB in 23 non-diabetic individuals with obesity and 14 healthy, non-obesity controls. Parametric images of binding potential BP ND were generated from the PET data and analyzed together with HbA1c levels by using volume of interest analysis for brain areas relevant to appetite control. Voxel-based morphometry (VBM) of individual magnetic resonance imaging data was further performed to correlate grey matter density (GMD) maps with HbA1c. We found significant negative correlations between HbA1c levels and BP ND in right and left hippocampus in obesity (r = − 0.717, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-78227-z