SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly over the world and claimed million lives. The virus evolves constantly, and a swarm of mutants is a now major concern globally. Distinct variants could have independently converged on same mutation, despite being detected in...

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Bibliographic Details
Published in:Infection and drug resistance 2022-01, Vol.15, p.373-385
Main Authors: Yang, Wan-Ting, Huang, Wei-Hsuan, Liao, Tsai-Ling, Hsiao, Tzu-Hung, Chuang, Han-Ni, Liu, Po-Yu
Format: Article
Language:English
Subjects:
Binding sites
coronavirus spike glycoprotein
Coronaviruses
COVID-19
Disease transmission
e484k
Epidemiology
Genetic aspects
Glycoproteins
Immune evasion
Microscopy
Monoclonal antibodies
monoclonal antibody
Mutation
Pandemics
Plasma
Proteins
Public health
Review
sars-cov-2 convalescent sera treatment
sars-cov-2 variant
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
vaccine
Vaccines
Viruses
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Summary:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly over the world and claimed million lives. The virus evolves constantly, and a swarm of mutants is a now major concern globally. Distinct variants could have independently converged on same mutation, despite being detected in different geographic regions, which suggested it could confer an evolutionary advantage. E484K has rapidly emerged and has frequently been detected in several SARS-CoV-2 variants of concern. In this study, we review the epidemiology and impact of E484K, its effects on neutralizing effect of several monoclonal antibodies, convalescent plasma, and post-vaccine sera.
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S344099