Chromosome Level Genome Assembly of Andrographis paniculata

Andrographis paniculata (Chinese name: Chuanxinlian) is an annual dicotyledonous medicinal plant widely grown in China and Southeast Asia. The dried plant has a highly acclaimed usage in the traditional Chinese medicine for its antipyretic, anti-inflammatory, and analgesic effects. In order to help...

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Bibliographic Details
Published in:Frontiers in genetics 2020-06, Vol.11, p.701-701
Main Authors: Liang, Ying, Chen, Shanshan, Wei, Kunhua, Yang, Zijiang, Duan, Shengchang, Du, Yuan, Qu, Peng, Miao, Jianhua, Chen, Wei, Dong, Yang
Format: Article
Language:English
Subjects:
Andrographis paniculata
Genetics
genome assembly
Hi-C
medicinal plant
PacBio sequencing
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Summary:Andrographis paniculata (Chinese name: Chuanxinlian) is an annual dicotyledonous medicinal plant widely grown in China and Southeast Asia. The dried plant has a highly acclaimed usage in the traditional Chinese medicine for its antipyretic, anti-inflammatory, and analgesic effects. In order to help delineate the biosynthetic pathways of various secondary metabolites, we report in this study a high-quality reference genome for A. paniculata . With the help of both PacBio single molecule real time sequencing and Illumina sequencing reads for error correction, the A. paniculata genome was assembled into a total size of 284 Mb with a contig N50 size of 5.14 Mb. The contigs were further assembled into 24 pseudo-chromosomes by the Hi-C technique. We also analyzed the gene families (e.g., KSL , and CYP450 ) whose protein products are essential for synthesizing bioactive compounds in A. paniculata. In conclusion, the high-quality A. paniculata genome assembly builds the foundation for decoding the biosynthetic pathways of various medicinal compounds.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2020.00701