FREQUENCY AND CORRELATES OF MYOPATHY IN PATIENTS WITH DIABETES TAKING ATORVASTATIN

Objective: To determine the myopathy in patients with diabetes taking atorvastatin and look for the factors correlated with the presence of myopathy among these patients. Study Design: Cross sectional analytical study. Place and Duration of Study: Department of Medicine, Pak Emirates Military Hospit...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2021-04, Vol.71 (2), p.482-85
Main Authors: Butt, Kamil Rehman, Khan, Andaleeb, Muhammad, Ali, Khan, Jawad, Ali, Ejaz, Zubair, Usama Bin
Format: Article
Language:English
Subjects:
Age groups
atorvastatin
Care and treatment
Clinical medicine
Creatinine
Diabetes
diabetes mellitus
Diabetes therapy
Diabetics
Enzymes
Gender
Hospitals
Hypercholesterolemia
Medical research
myopathy
Patients
Rhabdomyolysis
Statins
Type 2 diabetes
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Summary:Objective: To determine the myopathy in patients with diabetes taking atorvastatin and look for the factors correlated with the presence of myopathy among these patients. Study Design: Cross sectional analytical study. Place and Duration of Study: Department of Medicine, Pak Emirates Military Hospital Rawalpindi from, Jul to Dec 2018. Methodology: A total of 166 patients of both genders with type 2 diabetes mellitus taking atorvastatin for at least three to twelve months were included. Blood samples were drawn and Creatinine kinase (CK) levels were determined by automated analysis by colorimetry. Myopathy was taken as muscle symptoms associated with elevations in Creatinine Kinase at least 10 times the upper limit of normal. Results: Mean age of patients was 51.530 ± 5.70 years with age range from 40-70 years with. Mean duration of diabetes was 6.174 ± 2.27 years, mean duration of taking atorvastatin 7.186 ± 2.17 months and mean creatinine kinase levels were 1760.325 ± 5111.71 IU/L. Males were 68.7% as compare to females 31.3%. Myopathy was seen in 8.4% patients. Long duration of Diabetes Mellitus and atorvastatin use was statistically significantly related with the presence of myopathy. Conclusion: Myopathy was found in a significant number of patients taking atorvastatin. High risk population in our study emerged out to be patients with long duration of Diabetes Mellitus and long use of atorvastatin.
ISSN:0030-9648
2411-8842
DOI:10.51253/pafmj.v71i2.2924