Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group

Women infected with toxoplasmosis during pregnancy do not present symptoms in most cases, but the consequences of the congenital infection may be severe for the unborn child. Fetal damage can range from asymptomatic to severe neurological alterations to retinal lesions prone to potential flare up an...

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Bibliographic Details
Published in:Pathogens (Basel) 2019-02, Vol.8 (1), p.24
Main Authors: Peyron, François, L'ollivier, Coralie, Mandelbrot, Laurent, Wallon, Martine, Piarroux, Renaud, Kieffer, François, Hadjadj, Eve, Paris, Luc, Garcia-Meric, Patricia
Format: Article
Language:English
Subjects:
Congenital diseases
Congenital infection
congenital toxoplasmosis
Diagnosis
Epidemiology
Fetuses
follow-up of congenital infection
Genetic diversity
Gestational age
guidelines
Infections
Life Sciences
Medical diagnosis
Opinion
Parasites
Placenta
Pregnancy
Prevention
Public health
Quantitative Methods
Questionnaires
Serology
Signs and symptoms
Tempering
Toxoplasmosis
treatment of fetal infections
Virulence
Womens health
Working groups
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Summary:Women infected with toxoplasmosis during pregnancy do not present symptoms in most cases, but the consequences of the congenital infection may be severe for the unborn child. Fetal damage can range from asymptomatic to severe neurological alterations to retinal lesions prone to potential flare up and relapses lifelong. Despite the possible severity of outcome, congenital toxoplasmosis (CT) is a neglected disease. There is no consensus regarding screening during pregnancy, prenatal/postnatal treatment or short or medium term follow-up. Since 1992, France has offered systematic serological testing to non-immune pregnant women, monthly until delivery. Any maternal infection is thus detected; moreover, diagnosis of congenital infection can be made at birth and follow-up can be provided. "Guidelines" drawn up by a multidisciplinary group are presented here, concerning treatment, before and after birth. The recommendations are based on the regular analysis of the literature and the results of the working group. The evaluation of the recommendations takes into account the robustness of the recommendation and the quality of the evidence.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens8010024