Non-rapid eye movement sleep determines resilience to social stress

Resilience, the ability to overcome stressful conditions, is found in most mammals and varies significantly among individuals. A lack of resilience can lead to the development of neuropsychiatric and sleep disorders, often within the same individual. Despite extensive research into the brain mechani...

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Published in:eLife 2022-09, Vol.11
Main Authors: Bush, Brittany J, Donnay, Caroline, Andrews, Eva-Jeneé A, Lewis-Sanders, Darielle, Gray, Cloe L, Qiao, Zhimei, Brager, Allison J, Johnson, Hadiya, Brewer, Hamadi C S, Sood, Sahil, Saafir, Talib, Benveniste, Morris, Paul, Ketema N, Ehlen, J Christopher
Format: Article
Language:English
Subjects:
Animals
Eye Movements
Hypotheses
Male
Mammals
Mental disorders
Mice
Mice, Inbred C57BL
Neuroscience
non-rapid eye movement
NREM sleep
Prefrontal Cortex
REM sleep
resilience
Sleep
Sleep deprivation
Sleep disorders
social avoidance
social defeat stress
Social interaction
Social interactions
Stress
Stress, Psychological - psychology
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Summary:Resilience, the ability to overcome stressful conditions, is found in most mammals and varies significantly among individuals. A lack of resilience can lead to the development of neuropsychiatric and sleep disorders, often within the same individual. Despite extensive research into the brain mechanisms causing maladaptive behavioral-responses to stress, it is not clear why some individuals exhibit resilience. To examine if sleep has a determinative role in maladaptive behavioral-response to social stress, we investigated individual variations in resilience using a social-defeat model for male mice. Our results reveal a direct, causal relationship between sleep amount and resilience-demonstrating that sleep increases after social-defeat stress only occur in resilient mice. Further, we found that within the prefrontal cortex, a regulator of maladaptive responses to stress, pre-existing differences in sleep regulation predict resilience. Overall, these results demonstrate that increased NREM sleep, mediated cortically, is an active response to social-defeat stress that plays a determinative role in promoting resilience. They also show that differences in resilience are strongly correlated with inter-individual variability in sleep regulation.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.80206