HPV Infection and Prognostic Factors of Tongue Squamous Cell Carcinoma in Different Ethnic Groups from Geographically Closed Cohort in Xinjiang, China

Background. The effect of HPV infection status and ethnic differences on the prognosis of tongue squamous cell carcinoma in Xinjiang presents an interesting set of conditions that has yet to be studied. Methods. A comprehensive analysis of clinical data was undertaken for a cohort consisting of 63 p...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry Research International 2016-01, Vol.2016 (2016), p.294-298
Main Authors: Chen, Xinhua, Bao, Yongxing, Zhang, Songan, Zhang, Lei, Liu, Pan, Niyaz, Huerxidan, Zhao, Huarong, Zhang, Yang, Zhang, Hua, Reheman, Yiming
Format: Article
Language:English
Subjects:
Cancer therapies
Cervical cancer
Chemotherapy
Deoxyribonucleic acid
DNA
Hospitals
Human papillomavirus
Human papillomavirus 16
Human papillomavirus 18
Infections
Lymphatic system
Medical prognosis
Metastasis
Multivariate analysis
Papillomavirus infections
Physiological aspects
Prognosis
Radiation therapy
Statistical analysis
Studies
Surgery
Survival analysis
Tongue cancer
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. The effect of HPV infection status and ethnic differences on the prognosis of tongue squamous cell carcinoma in Xinjiang presents an interesting set of conditions that has yet to be studied. Methods. A comprehensive analysis of clinical data was undertaken for a cohort consisting of 63 patients with tongue squamous cell carcinoma recruited from three ethnic groups in Xinjiang. PCR was used for the detection of HPV16 and HPV18 infections. Kaplan-Meier survival analysis was used for analyzing survival outcome in addition to the assessment of other prognostic factors. Results. The overall infection rate for HPV was 28.6% (18/63); the 5-year survival rate among the HPV-positive patients was 47.8% and 30.3% for HPV-negative patients. The survival rate for HPV-positive patients who received radiotherapy and chemotherapy was better than for those who did not receive radiotherapy and chemotherapy. N staging and HPV infection were found to be two independent and significant prognostic factors. Conclusion. HPV-positive patients with tongue squamous cell carcinoma are more sensitive to chemotherapy. Higher N staging indicates poor prognosis.
ISSN:2090-2247
2090-2255
DOI:10.1155/2016/7498706