Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Plant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in the family of Rutaceae (Genera , , , and ). Due to several significant biological activities, such as antitumor, antibacterial, antiviral, antidiabetic, anti-HIV and neuroprotective activities of the parent s...

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Bibliographic Details
Published in:Antioxidants 2022-03, Vol.11 (3), p.493
Main Authors: Tan, Mario A, Sharma, Niti, An, Seong Soo A
Format: Article
Language:English
Subjects:
Alkaloids
Alzheimer's disease
Antioxidants
Cancer
Carbazole
Cognitive ability
Cytokines
Diabetes mellitus
FDA approval
HIV
Human immunodeficiency virus
Memory
Mitochondria
neurodegenerative disease
Neurodegenerative diseases
neuroinflammation
Neuroprotection
Nitric oxide
Oxidative stress
phyto carbazole alkaloid
Plants
Protein folding
Review
Rutaceae
Tumor necrosis factor-TNF
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Summary:Plant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in the family of Rutaceae (Genera , , , and ). Due to several significant biological activities, such as antitumor, antibacterial, antiviral, antidiabetic, anti-HIV and neuroprotective activities of the parent skeleton (3-methylcarbazole), carbazole alkaloids are recognized as an important class of potential therapeutic agents. Neurodegenerative diseases (NDs) may exhibit a vast range of conditions, affecting neurons primarily and leading ultimately to the progressive losses of normal motor and cognitive functions. The main pathophysiological indicators of NDs comprise increasing atypical protein folding, oxidative stresses, mitochondrial dysfunctions, deranged neurotransmissions and neuronal losses. Phyto-carbazole alkaloids can be investigated for exerting multitarget approaches to ameliorating NDs. This review presents a comprehensive evaluation of the available scientific literature on the neuroprotective mechanisms of phyto-carbazole alkaloids from the Rutaceae family in ameliorating NDs.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11030493