Morphological and Hemodynamic Changes during Cerebral Aneurysm Growth

Computational fluid dynamics (CFD) has grown as a tool to help understand the hemodynamic properties related to the rupture of cerebral aneurysms. Few of these studies deal specifically with aneurysm growth and most only use a single time instance within the aneurysm growth history. The present retr...

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Bibliographic Details
Published in:Brain sciences 2021-04, Vol.11 (4), p.520
Main Authors: Nordahl, Emily R, Uthamaraj, Susheil, Dennis, Kendall D, Sejkorová, Alena, Hejčl, Aleš, Hron, Jaroslav, Švihlová, Helena, Carlson, Kent D, Suzen, Yildirim Bora, Dragomir-Daescu, Dan
Format: Article
Language:English
Subjects:
Aneurysm
aneurysm growth
Aneurysms
Communication
computational fluid dynamics
Computer applications
hemodynamics
Image processing
Kinetic energy
Medical imaging
Morphology
oscillatory shear index
Software
Velocity
wall shear stress
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Summary:Computational fluid dynamics (CFD) has grown as a tool to help understand the hemodynamic properties related to the rupture of cerebral aneurysms. Few of these studies deal specifically with aneurysm growth and most only use a single time instance within the aneurysm growth history. The present retrospective study investigated four patient-specific aneurysms, once at initial diagnosis and then at follow-up, to analyze hemodynamic and morphological changes. Aneurysm geometries were segmented via the medical image processing software Mimics. The geometries were meshed and a computational fluid dynamics (CFD) analysis was performed using ANSYS. Results showed that major geometry bulk growth occurred in areas of low wall shear stress (WSS). Wall shape remodeling near neck impingement regions occurred in areas with large gradients of WSS and oscillatory shear index. This study found that growth occurred in areas where low WSS was accompanied by high velocity gradients between the aneurysm wall and large swirling flow structures. A new finding was that all cases showed an increase in kinetic energy from the first time point to the second, and this change in kinetic energy seems correlated to the change in aneurysm volume.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci11040520