Seizure: An Adverse Effect of Regadenoson in Myocardial Perfusion Imaging

Regadenoson is a selective adenosine 2a (A2a) receptor agonist that is used in cardiac stress testing to evaluate for ischemic heart disease and has largely replaced adenosine in the modern era. Since adenosine receptors are involved in synaptic transmission between neurons throughout the central ne...

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Bibliographic Details
Published in:Case reports in cardiology 2019-01, Vol.2019 (2019), p.1-3
Main Authors: Radwan, Sohab S., Schwartz, Owen G.
Format: Article
Language:English
Subjects:
Adenosine
Cardiology
Case Report
Case reports
Convulsions & seizures
Coronary vessels
Electrocardiography
Heart rate
Medical imaging
NMR
Nuclear magnetic resonance
Nuclear medicine
Patients
Smooth muscle
Veins & arteries
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Summary:Regadenoson is a selective adenosine 2a (A2a) receptor agonist that is used in cardiac stress testing to evaluate for ischemic heart disease and has largely replaced adenosine in the modern era. Since adenosine receptors are involved in synaptic transmission between neurons throughout the central nervous system (CNS) including the cerebral cortex, hippocampus, and other structures as well, regadenoson can lower the seizure threshold in susceptible individuals. Epileptogenic activity is an uncommon yet potentially severe adverse effect of regadenoson use, and therefore, more awareness is required in screening patients at risk and evaluating alternate ways to investigate coronary artery disease (CAD) in susceptible individuals.
ISSN:2090-6404
2090-6412
DOI:10.1155/2019/6240605