Lymphocyte-Specific Biomarkers Associated With Preterm Birth and Bronchopulmonary Dysplasia

Many premature babies who are born with neonatal respiratory distress syndrome (RDS) go on to develop Bronchopulmonary Dysplasia (BPD) and later Post-Prematurity Respiratory Disease (PRD) at one year corrected age, characterized by persistent or recurrent lower respiratory tract symptoms frequently...

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Bibliographic Details
Published in:Frontiers in immunology 2021-01, Vol.11, p.563473-563473
Main Authors: Bhattacharya, Soumyaroop, Mereness, Jared A, Baran, Andrea M, Misra, Ravi S, Peterson, Derick R, Ryan, Rita M, Reynolds, Anne Marie, Pryhuber, Gloria S, Mariani, Thomas J
Format: Article
Language:English
Subjects:
Biomarkers - blood
bronchopulmonary dysplasia
Bronchopulmonary Dysplasia - blood
Bronchopulmonary Dysplasia - genetics
CD8+ lymphocytes
CD8-Positive T-Lymphocytes - immunology
Female
Gestational Age
Humans
Immunology
Infant, Extremely Premature - blood
Infant, Newborn
Lymphocyte Activation
Male
Newborn Lung, Peripheral Blood Mononucleated cells
Pregnancy
Premature Birth - blood
Premature Birth - genetics
prematurity and respiratory outcomes program
Prognosis
Respiratory Distress Syndrome, Newborn - blood
Respiratory Distress Syndrome, Newborn - genetics
RNA-Seq
RNA-sequencing, Pathway
Transcriptome - genetics
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Summary:Many premature babies who are born with neonatal respiratory distress syndrome (RDS) go on to develop Bronchopulmonary Dysplasia (BPD) and later Post-Prematurity Respiratory Disease (PRD) at one year corrected age, characterized by persistent or recurrent lower respiratory tract symptoms frequently related to inflammation and viral infection. Transcriptomic profiles were generated from sorted peripheral blood CD8+ T cells of preterm and full-term infants enrolled with consent in the NHLBI Prematurity and Respiratory Outcomes Program (PROP) at the University of Rochester and the University at Buffalo. We identified outcome-related gene expression patterns following standard methods to identify markers for oxygen utilization and BPD as outcomes in extremely premature infants. We further identified predictor gene sets for BPD based on transcriptomic data adjusted for gestational age at birth (GAB). RNA-Seq analysis was completed for CD8+ T cells from 145 subjects. Among the subjects with highest risk for BPD (born at
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.563473