The systemic inflammatory response index is associated with chronic kidney disease in patients with hypertension: data from the national health and nutrition examination study 1999-2018

Studies have shown that in hypertensive patients, chronic kidney disease (CKD) is associated with a poor prognosis. Inflammation is a highly important factor in the progression of CKD. Detecting systemic inflammation and intervening promptly in patients with hypertension may help reduce the risk of...

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Bibliographic Details
Published in:Renal failure 2024-12, Vol.46 (2), p.2396459
Main Authors: Wang, Yani, Liao, Lihua, Guo, Qian, Liao, Ying, Lin, Xueqin, Li, Huilan, Deng, Lin, Deng, Yufei, Guo, Danni, Chen, Kaihong, Fang, Yong
Format: Article
Language:English
Subjects:
Adult
Aged
chronic kidney disease
Chronic Kidney Disease and Progression
Cross-Sectional Studies
Disease Progression
Female
Humans
Hypertension
Hypertension - complications
Hypertension - epidemiology
Inflammation
Logistic Models
Male
Middle Aged
NHANES
Nutrition Surveys
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - epidemiology
Risk Factors
systemic inflammatory response index (SIRI)
United States - epidemiology
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Summary:Studies have shown that in hypertensive patients, chronic kidney disease (CKD) is associated with a poor prognosis. Inflammation is a highly important factor in the progression of CKD. Detecting systemic inflammation and intervening promptly in patients with hypertension may help reduce the risk of CKD. The systemic inflammatory response index (SIRI) is a tool used to measure the systemic inflammatory response, but its relationship with CKD in patients with hypertension remains uncertain. We utilized data from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 1999 and 2018. The analysis included a total of 20,243 participants, categorized into three groups based on SIRI tertiles. Logistic regression analysis and restricted cubic spline analysis were used to examine the relationship between the SIRI and CKD. In patients with hypertension, there was a notable relationship between the SIRI and the odds of developing CKD. After full adjustment, there was a 31% greater likelihood of developing CKD associated with each incremental increase of 1 unit in the SIRI (OR: 1.31, 95% CI: 1.24-1.39,  
ISSN:0886-022X
1525-6049
1525-6049
DOI:10.1080/0886022X.2024.2396459