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The systemic inflammatory response index is associated with chronic kidney disease in patients with hypertension: data from the national health and nutrition examination study 1999-2018
Studies have shown that in hypertensive patients, chronic kidney disease (CKD) is associated with a poor prognosis. Inflammation is a highly important factor in the progression of CKD. Detecting systemic inflammation and intervening promptly in patients with hypertension may help reduce the risk of...
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| Published in: | Renal failure 2024-12, Vol.46 (2), p.2396459 |
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| container_title | Renal failure |
| container_volume | 46 |
| creator | Wang, Yani Liao, Lihua Guo, Qian Liao, Ying Lin, Xueqin Li, Huilan Deng, Lin Deng, Yufei Guo, Danni Chen, Kaihong Fang, Yong |
| description | Studies have shown that in hypertensive patients, chronic kidney disease (CKD) is associated with a poor prognosis. Inflammation is a highly important factor in the progression of CKD. Detecting systemic inflammation and intervening promptly in patients with hypertension may help reduce the risk of CKD. The systemic inflammatory response index (SIRI) is a tool used to measure the systemic inflammatory response, but its relationship with CKD in patients with hypertension remains uncertain.
We utilized data from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 1999 and 2018. The analysis included a total of 20,243 participants, categorized into three groups based on SIRI tertiles. Logistic regression analysis and restricted cubic spline analysis were used to examine the relationship between the SIRI and CKD.
In patients with hypertension, there was a notable relationship between the SIRI and the odds of developing CKD. After full adjustment, there was a 31% greater likelihood of developing CKD associated with each incremental increase of 1 unit in the SIRI (OR: 1.31, 95% CI: 1.24-1.39,
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| doi_str_mv | 10.1080/0886022X.2024.2396459 |
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We utilized data from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 1999 and 2018. The analysis included a total of 20,243 participants, categorized into three groups based on SIRI tertiles. Logistic regression analysis and restricted cubic spline analysis were used to examine the relationship between the SIRI and CKD.
In patients with hypertension, there was a notable relationship between the SIRI and the odds of developing CKD. After full adjustment, there was a 31% greater likelihood of developing CKD associated with each incremental increase of 1 unit in the SIRI (OR: 1.31, 95% CI: 1.24-1.39,
< 0.001). The groups with greater SIRI values exhibited greater odds of developing CKD than did the T1 group (T2: OR: 1.20, 95% CI: 1.04-1.38,
= 0.015; T3: OR: 1.69, 95% CI: 1.47-1.94,
< 0.001).
A high SIRI is associated with an increased risk of CKD in hypertensive patients. The greater the SIRI is, the greater the risk of CKD in hypertensive patients.</description><identifier>ISSN: 0886-022X</identifier><identifier>ISSN: 1525-6049</identifier><identifier>EISSN: 1525-6049</identifier><identifier>DOI: 10.1080/0886022X.2024.2396459</identifier><identifier>PMID: 39311633</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adult ; Aged ; chronic kidney disease ; Chronic Kidney Disease and Progression ; Cross-Sectional Studies ; Disease Progression ; Female ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - epidemiology ; Inflammation ; Logistic Models ; Male ; Middle Aged ; NHANES ; Nutrition Surveys ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - epidemiology ; Risk Factors ; systemic inflammatory response index (SIRI) ; United States - epidemiology</subject><ispartof>Renal failure, 2024-12, Vol.46 (2), p.2396459</ispartof><rights>2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2024 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-8435163d7b4a2ef67cc81c3e9d64c1a01b402758e81e0d4d39cfa564b353ea253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421140/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421140/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,37000,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39311633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yani</creatorcontrib><creatorcontrib>Liao, Lihua</creatorcontrib><creatorcontrib>Guo, Qian</creatorcontrib><creatorcontrib>Liao, Ying</creatorcontrib><creatorcontrib>Lin, Xueqin</creatorcontrib><creatorcontrib>Li, Huilan</creatorcontrib><creatorcontrib>Deng, Lin</creatorcontrib><creatorcontrib>Deng, Yufei</creatorcontrib><creatorcontrib>Guo, Danni</creatorcontrib><creatorcontrib>Chen, Kaihong</creatorcontrib><creatorcontrib>Fang, Yong</creatorcontrib><title>The systemic inflammatory response index is associated with chronic kidney disease in patients with hypertension: data from the national health and nutrition examination study 1999-2018</title><title>Renal failure</title><addtitle>Ren Fail</addtitle><description>Studies have shown that in hypertensive patients, chronic kidney disease (CKD) is associated with a poor prognosis. Inflammation is a highly important factor in the progression of CKD. Detecting systemic inflammation and intervening promptly in patients with hypertension may help reduce the risk of CKD. The systemic inflammatory response index (SIRI) is a tool used to measure the systemic inflammatory response, but its relationship with CKD in patients with hypertension remains uncertain.
We utilized data from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 1999 and 2018. The analysis included a total of 20,243 participants, categorized into three groups based on SIRI tertiles. Logistic regression analysis and restricted cubic spline analysis were used to examine the relationship between the SIRI and CKD.
In patients with hypertension, there was a notable relationship between the SIRI and the odds of developing CKD. After full adjustment, there was a 31% greater likelihood of developing CKD associated with each incremental increase of 1 unit in the SIRI (OR: 1.31, 95% CI: 1.24-1.39,
< 0.001). The groups with greater SIRI values exhibited greater odds of developing CKD than did the T1 group (T2: OR: 1.20, 95% CI: 1.04-1.38,
= 0.015; T3: OR: 1.69, 95% CI: 1.47-1.94,
< 0.001).
A high SIRI is associated with an increased risk of CKD in hypertensive patients. The greater the SIRI is, the greater the risk of CKD in hypertensive patients.</description><subject>Adult</subject><subject>Aged</subject><subject>chronic kidney disease</subject><subject>Chronic Kidney Disease and Progression</subject><subject>Cross-Sectional Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - epidemiology</subject><subject>Inflammation</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>NHANES</subject><subject>Nutrition Surveys</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Risk Factors</subject><subject>systemic inflammatory response index (SIRI)</subject><subject>United States - epidemiology</subject><issn>0886-022X</issn><issn>1525-6049</issn><issn>1525-6049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkstuFDEQRVsIRCaBTwB5yaYHP_vBBqEIQqRIbILEzqqxq9MO3fZgeyD9afwdnswkIgvLUvncW2X7VtUbRteMdvQ97bqGcv5jzSmXay76Rqr-WbViiqu6obJ_Xq32TL2HTqrTlG4pZapr-cvqRPSCsUaIVfX3ekSSlpRxdoY4P0wwz5BDXEjEtA0-YalavCMuEUgpGAcZLfnj8kjMGIMvsp_OelyIdQnhnidbyA59TgduXLYYM_rkgv9ALGQgQwwzyaW3L2TwMJERYSoseEv8Lke3LxO8g9kdEJLyzi6E9X1fc8q6V9WLAaaEr4_7WfX9y-fr86_11beLy_NPV7URqsl1J4UqV7XtRgLHoWmN6ZgR2NtGGgaUbSTlreqwY0ittKI3A6hGboQSCFyJs-ry4GsD3OptdDPERQdw-r4Q4o2GmJ2ZUFPeIMdW4sYwyUwLA2-4ZUZK2wvVNcXr48Fru9vMaE15ogjTE9OnJ96N-ib81oxJXhYtDu-ODjH82mHKenbJ4DSBx7BLWpRwlN_tpCyoOqAmhpQiDo99GNX7DOmHDOl9hvQxQ0X39v8hH1UPoRH_APmoxpA</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Wang, Yani</creator><creator>Liao, Lihua</creator><creator>Guo, Qian</creator><creator>Liao, Ying</creator><creator>Lin, Xueqin</creator><creator>Li, Huilan</creator><creator>Deng, Lin</creator><creator>Deng, Yufei</creator><creator>Guo, Danni</creator><creator>Chen, Kaihong</creator><creator>Fang, Yong</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>202412</creationdate><title>The systemic inflammatory response index is associated with chronic kidney disease in patients with hypertension: data from the national health and nutrition examination study 1999-2018</title><author>Wang, Yani ; Liao, Lihua ; Guo, Qian ; Liao, Ying ; Lin, Xueqin ; Li, Huilan ; Deng, Lin ; Deng, Yufei ; Guo, Danni ; Chen, Kaihong ; Fang, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-8435163d7b4a2ef67cc81c3e9d64c1a01b402758e81e0d4d39cfa564b353ea253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>chronic kidney disease</topic><topic>Chronic Kidney Disease and Progression</topic><topic>Cross-Sectional Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - epidemiology</topic><topic>Inflammation</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>NHANES</topic><topic>Nutrition Surveys</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Risk Factors</topic><topic>systemic inflammatory response index (SIRI)</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yani</creatorcontrib><creatorcontrib>Liao, Lihua</creatorcontrib><creatorcontrib>Guo, Qian</creatorcontrib><creatorcontrib>Liao, Ying</creatorcontrib><creatorcontrib>Lin, Xueqin</creatorcontrib><creatorcontrib>Li, Huilan</creatorcontrib><creatorcontrib>Deng, Lin</creatorcontrib><creatorcontrib>Deng, Yufei</creatorcontrib><creatorcontrib>Guo, Danni</creatorcontrib><creatorcontrib>Chen, Kaihong</creatorcontrib><creatorcontrib>Fang, Yong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Renal failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yani</au><au>Liao, Lihua</au><au>Guo, Qian</au><au>Liao, Ying</au><au>Lin, Xueqin</au><au>Li, Huilan</au><au>Deng, Lin</au><au>Deng, Yufei</au><au>Guo, Danni</au><au>Chen, Kaihong</au><au>Fang, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The systemic inflammatory response index is associated with chronic kidney disease in patients with hypertension: data from the national health and nutrition examination study 1999-2018</atitle><jtitle>Renal failure</jtitle><addtitle>Ren Fail</addtitle><date>2024-12</date><risdate>2024</risdate><volume>46</volume><issue>2</issue><spage>2396459</spage><pages>2396459-</pages><issn>0886-022X</issn><issn>1525-6049</issn><eissn>1525-6049</eissn><abstract>Studies have shown that in hypertensive patients, chronic kidney disease (CKD) is associated with a poor prognosis. Inflammation is a highly important factor in the progression of CKD. Detecting systemic inflammation and intervening promptly in patients with hypertension may help reduce the risk of CKD. The systemic inflammatory response index (SIRI) is a tool used to measure the systemic inflammatory response, but its relationship with CKD in patients with hypertension remains uncertain.
We utilized data from the National Health and Nutrition Examination Survey (NHANES), which was conducted between 1999 and 2018. The analysis included a total of 20,243 participants, categorized into three groups based on SIRI tertiles. Logistic regression analysis and restricted cubic spline analysis were used to examine the relationship between the SIRI and CKD.
In patients with hypertension, there was a notable relationship between the SIRI and the odds of developing CKD. After full adjustment, there was a 31% greater likelihood of developing CKD associated with each incremental increase of 1 unit in the SIRI (OR: 1.31, 95% CI: 1.24-1.39,
< 0.001). The groups with greater SIRI values exhibited greater odds of developing CKD than did the T1 group (T2: OR: 1.20, 95% CI: 1.04-1.38,
= 0.015; T3: OR: 1.69, 95% CI: 1.47-1.94,
< 0.001).
A high SIRI is associated with an increased risk of CKD in hypertensive patients. The greater the SIRI is, the greater the risk of CKD in hypertensive patients.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>39311633</pmid><doi>10.1080/0886022X.2024.2396459</doi><oa>free_for_read</oa></addata></record> |
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| source | Publicly Available Content Database; Taylor & Francis Open Access Journals; PubMed Central |
| subjects | Adult Aged chronic kidney disease Chronic Kidney Disease and Progression Cross-Sectional Studies Disease Progression Female Humans Hypertension Hypertension - complications Hypertension - epidemiology Inflammation Logistic Models Male Middle Aged NHANES Nutrition Surveys Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - epidemiology Risk Factors systemic inflammatory response index (SIRI) United States - epidemiology |
| title | The systemic inflammatory response index is associated with chronic kidney disease in patients with hypertension: data from the national health and nutrition examination study 1999-2018 |
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