Disulfiram-Induced Reversible Hypertension: A Prospective Case Series and Review of The Literature

Disulfiram (DSF) is one of the recommended aids in the management of selected patients with alcohol dependence. Hypertension (HTN) as an adverse effect of DSF therapy is less understood. In our prospective case series of 7 subjects with co-morbid alcohol and nicotine dependence, a temporal, dose-dep...

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Bibliographic Details
Published in:Indian journal of psychological medicine 2014-10, Vol.36 (4), p.434-438
Main Authors: Kulkarni, Ranganath R., Ramdurg, Santosh I., Bairy, Bhavya K.
Format: Article
Language:English
Subjects:
Adverse effect
Alcoholism
Blood pressure
Case Report
Compliance
Dehydrogenases
Diabetes
Disulfiram
Dopamine
Drug dosages
Enzymes
Hypertension
Literature reviews
LSD
Lysergic acid diethylamide
Mortality
Nervous system
Patients
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Summary:Disulfiram (DSF) is one of the recommended aids in the management of selected patients with alcohol dependence. Hypertension (HTN) as an adverse effect of DSF therapy is less understood. In our prospective case series of 7 subjects with co-morbid alcohol and nicotine dependence, a temporal, dose-dependent, and reversible grade 1-3 HTN within 1-6 weeks of initiation of DSF therapy (125-500 mg/day) with no other detectable causes of HTN was noted. Challenges and strategies surrounding diagnosis and treatment along with mean change and percentage rise in blood pressure are described. Literature review and clinical description of case series may suggest neurobiological role in its causation. HTN may be a clinically significant, dose-dependent, and reversible adverse effect of DSF therapy, especially in co-morbid alcohol and nicotine-dependent patients. Awareness amongst clinicians may render better health care delivery to subjects with alcohol dependence.
ISSN:0253-7176
0975-1564
DOI:10.4103/0253-7176.140744