Perceived utility and feasibility of pathogen genomics for public health practice: a survey among public health professionals working in the field of infectious diseases, Belgium, 2019

• Published in: BMC public health 2020-08, Vol.20 (1), p.1318-1318, Article 1318
• Main Authors: Van Goethem, N, Struelens, M J, De Keersmaecker, S C J, Roosens, N H C, Robert, A, Quoilin, S, Van Oyen, H, Devleesschauwer, B
• Format: Article
• Language: English
• Subjects: Adult; Attitude of Health Personnel; Attitudes; Belgium; Beliefs, opinions and attitudes; Bioinformatics; Biologists; Biology; Communicable Diseases - genetics; Data integration; Data retrieval; Diagnostic systems; Disease control; Disease prevention; DNA sequencing; Epidemics; Epidemiology; Feasibility; Feasibility Studies; Female; Food safety; Frequency distribution; Genetic aspects; Genomes; Genomics; Genomics - methods; Health behavior; Health Personnel - psychology; Hospitals; Humans; Infections; Infectious diseases; Information sharing; Laboratories; Literacy; Male; Medical personnel; Microbiology; Middle Aged; Multiple choice; Next-generation sequencing; pathogen genomics; Pathogenic microorganisms; Pathogens; Polls & surveys; Population; Professionals; Public health; Public Health - methods; Public health personnel; Public health practice; Public opinion; Questionnaires; Regression analysis; Regression models; Statistical analysis; survey; Surveys and Questionnaires; Training; User requirements; whole-genome sequencing
• ISSN: 1471-2458; 1471-2458
• DOI: 10.1186/s12889-020-09428-4

Pathogen genomics is increasingly being translated from the research setting into the activities of public health professionals operating at different levels. This survey aims to appraise the literacy level and gather the opinions of public health experts and allied professionals working in the field of infectious diseases in Belgium concerning the implementation of next-generation sequencing (NGS) in public health practice. In May 2019, Belgian public health and healthcare professionals were invited to complete an online survey containing eight main topics including background questions, general attitude towards pathogen genomics for public health practice and main concerns, genomic literacy, current and planned NGS activities, place of NGS in diagnostic microbiology pathways, data sharing obstacles, end-user requirements, and key drivers for the implementation of NGS. Descriptive statistics were used to report on the frequency distribution of multiple choice responses whereas thematic analysis was used to analyze free text responses. A multivariable logistic regression model was constructed to identify important predictors for a positive attitude towards the implementation of pathogen genomics in public health practice. 146 out of the 753 invited public health professionals completed the survey. 63% of respondents indicated that public health agencies should be using genomics to understand and control infectious diseases. Having a high level of expertise in the field of pathogen genomics was the strongest predictor of a positive attitude (OR = 4.04, 95% CI = 1.11 - 17.23). A significantly higher proportion of data providers indicated to have followed training in the field of pathogen genomics compared to data end-users (p < 0.001). Overall, 79% of participants expressed interest in receiving further training. Main concerns were related to the cost of sequencing technologies, data sharing, data integration, interdisciplinary working, and bioinformatics expertise. Belgian health professionals expressed favorable views about implementation of pathogen genomics in their work activities related to infectious disease surveillance and control. They expressed the need for suitable training initiatives to strengthen their competences in the field. Their perception of the utility and feasibility of pathogen genomics for public health purposes will be a key driver for its further implementation.