Double Allogenic Mesenchymal Stem Cells Transplantations Could Not Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus

The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles. However, the optimum frequency of the MSCs transplantation (MSCT) is unknown. This study was undertaken to observe whether double transplantat...

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Bibliographic Details
Published in:Clinical & developmental immunology 2012-01, Vol.2012 (2012), p.1-7
Main Authors: Hua, Bingzhu, Liu, Bujun, Xu, Hu-Ji, Chen, Wanjun, Shi, Songtao, Sun, Ling-Yun, Wang, Dandan, Wang, Hong, Feng, Xuebing, Li, Xia, Akiyama, Kentaro, Zhang, Huayong, Yamaza, Takayoshi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Body weight
Bone marrow
Child
Clinical Study
Clinical trials
Disease-Free Survival
Female
Humans
Immunology
Lupus
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - therapy
Male
Mesenchymal Stem Cell Transplantation
Mesenchyme
Middle Aged
Remission
stem cell transplantation
Stem cells
Survival
Systemic lupus erythematosus
Young Adult
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Summary:The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles. However, the optimum frequency of the MSCs transplantation (MSCT) is unknown. This study was undertaken to observe whether double transplantations of MSCs is superior to single transplantation. Fifty-eight refractory SLE patients were enrolled in this study, in which 30 were randomly given single MSCT, and the other 28 were given double MSCT. Patients were followed up for rates of survival, disease remission, and relapse, as well as transplantation-related adverse events. SLE disease activity index (SLEDAI) and serologic features were evaluated. Our results showed that no remarkable differences between single and double allogenic MSCT were found in terms of disease remission and relapse, amelioration of disease activity, and serum indexes in an SLE clinical trial with more than one year followup. This study demonstrated that single MSCs transplantation at the dose of one million MSCs per kilogram of body weight was sufficient to induce disease remission for refractory SLE patients.
ISSN:1740-2522
2314-8861
1740-2530
2314-7156
DOI:10.1155/2012/273291