Multifunctional pMGF505-7R Is a Key Virulence-Related Factor of African Swine Fever Virus

African swine fever virus (ASFV) is the etiological agent of African swine fever (ASF), and it is an enveloped, icosahedral, double-stranded DNA virus with a genome length ranging from 170 to 193 kb. The ASFV genome contains at least five multigene families (MGFs): MGF100, MGF110, MGF300, MGF360, an...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in microbiology 2022-03, Vol.13, p.852431-852431
Main Authors: Huang, Li, Li, Jiangnan, Zheng, Jun, Li, Dan, Weng, Changjiang
Format: Article
Language:English
Subjects:
ASFV
inflammatory response
innate immune
Microbiology
multifunction
pMGF505-7R
virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:African swine fever virus (ASFV) is the etiological agent of African swine fever (ASF), and it is an enveloped, icosahedral, double-stranded DNA virus with a genome length ranging from 170 to 193 kb. The ASFV genome contains at least five multigene families (MGFs): MGF100, MGF110, MGF300, MGF360, and MGF505 at the right and left terminal variable regions. The members of the same MGF family are most similar and have conserved sequence motifs, whereas the genetic diversity of different MGF families varies widely. MGF genes play a crucial role in determining ASFV host range, virulence and reducing early cell death post-infection. pMGF505-7R is a multifunctional protein. Recent research advances of pMGF505-7R provide a few new clues to understand the functions of pMGF505-7R either in antagonizing the induction of type I IFN production and IFN downstream signaling or in suppressing inflammatory responses by inhibition of NF-κB signaling and NLRP3 inflammasome, which may be related to ASFV infection-induced pathogenesis.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2022.852431