An update on the biological characteristics and functions of tuft cells in the gut

The intestine is a powerful digestive system and one of the most sophisticated immunological organs. Evidence shows that tuft cells (TCs), a kind of epithelial cell with distinct morphological characteristics, play a significant role in various physiological processes. TCs can be broadly categorized...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2023-01, Vol.10, p.1102978-1102978
Main Authors: Du, Yixuan, Gao, Han, He, Chengwei, Xin, Shuzi, Wang, Boya, Zhang, Sitian, Gong, Fengrong, Yu, Xinyi, Pan, Luming, Sun, Fanglin, Wang, Wen, Xu, Jingdong
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
helminth infection
intestinal epithelial cell
tuft cell
tumor
type 2 immune response
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Summary:The intestine is a powerful digestive system and one of the most sophisticated immunological organs. Evidence shows that tuft cells (TCs), a kind of epithelial cell with distinct morphological characteristics, play a significant role in various physiological processes. TCs can be broadly categorized into different subtypes depending on different molecular criteria. In this review, we discuss its biological properties and role in maintaining homeostasis in the gastrointestinal tract. We also emphasize its relevance to the immune system and highlight its powerful influence on intestinal diseases, including inflammations and tumors. In addition, we provide fresh insights into future clinical diagnostic and therapeutic strategies related to TCs.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.1102978