Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs

Reactive oxygen species (ROS) play an important role in cell proliferation and differentiation. They are also by-products of aerobic living conditions. Their inherent reactivity poses a threat for all cellular components. Cells have, therefore, evolved complex pathways to sense and maintain the redo...

Full description

Saved in:
Bibliographic Details
Published in:Antioxidants 2021-06, Vol.10 (7), p.1030
Main Authors: Jenkins, Tabitha, Gouge, Jerome
Format: Article
Language:English
Subjects:
Adapter proteins
Apoptosis
Autophagy
Brf2
Cancer
Cell activation
Cell death
Cell differentiation
Cell proliferation
Cytoplasm
Detoxification
Enzymes
Ferroptosis
Genes
Homeostasis
Lipid peroxidation
Metabolism
Metastases
Nrf2
Oxidative stress
Reactive oxygen species
Review
Selenium
selenoproteins
transcription
Transcription factors
Tumorigenesis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Reactive oxygen species (ROS) play an important role in cell proliferation and differentiation. They are also by-products of aerobic living conditions. Their inherent reactivity poses a threat for all cellular components. Cells have, therefore, evolved complex pathways to sense and maintain the redox balance. Among them, Nrf2 (Nuclear factor erythroid 2-related factor 2) plays a crucial role: it is activated under oxidative conditions and is responsible for the expression of the detoxification machinery and antiapoptotic factors. It is, however, a double edge sword: whilst it prevents tumorigenesis in healthy cells, its constitutive activation in cancer promotes tumour growth and metastasis. In addition, recent data have highlighted the importance of Nrf2 in evading programmed cell death. In this review, we will focus on the activation of the Nrf2 pathway in the cytoplasm, the molecular basis underlying Nrf2 binding to the DNA, and the dysregulation of this pathway in cancer, before discussing how Nrf2 contributes to the prevention of apoptosis and ferroptosis in cancer and how it is likely to be linked to detoxifying enzymes containing selenium.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10071030