Body composition of children with moderate and severe undernutrition and after treatment: a narrative review

• Published in: BMC medicine 2019-11, Vol.17 (1), p.215-215, Article 215
• Main Author: Wells, Jonathan C K
• Format: Article
• Language: English
• Subjects: Adolescent; Age; Anorexia; Anthropometry; Body Composition; Body fat; Body Mass Index; Child; Child development; Child Nutrition Disorders - physiopathology; Child undernutrition; Child, Preschool; Childhood; Children; Children & youth; Communicable diseases; Composition effects; Dietary supplements; Edema; Fat-free body mass; Female; Growth Disorders - physiopathology; Health care; Health risks; Heterogeneity; Humans; Hydration; Infant; Male; Measurement techniques; Metabolism; Mortality; Muscles; NMR; Nuclear magnetic resonance; Nutrition research; Nutritional status; Organs; Physiological aspects; Review; Stunting; Undernutrition; Wasting; Wasting Syndrome - physiopathology
• ISSN: 1741-7015; 1741-7015
• DOI: 10.1186/s12916-019-1465-8

Until recently, undernourished children were usually assessed using simple anthropometric measurements, which provide global assessments of nutritional status. There is increasing interest in obtaining more direct data on body composition to assess the effects of undernutrition on fat-free mass (FFM) and its constituents, such as muscle and organs, and on fat mass (FM) and its regional distribution. Recent studies show that severe-acute undernutrition, categorised as 'wasting', is associated with major deficits in both FFM and FM that may persist in the long-term. Fat distribution appears more central, but this is more associated with the loss of peripheral fat than with the elevation of central fat. Chronic undernutrition, categorised as 'stunting', is associated with deficits in FFM and in specific components, such as organ size. However, the magnitude of these deficits is reduced, or - in some cases - disappears, after adjustment for height. This suggests that FFM is largely reduced in proportion to linear growth. Stunted children vary in their FM - in some cases remaining thin throughout childhood, but in other cases developing higher levels of FM. The causes of this heterogeneity remain unclear. Several different pathways may underlie longitudinal associations between early stunting and later body composition. Importantly, recent studies suggest that short children are not at risk of excess fat deposition in the short term when given nutritional supplementation. The short- and long-term functional significance of FFM and FM for survival, physical capacity and non-communicable disease risk means that both tissues merit further attention in research on child undernutrition.