J-shaped relationship of serum neurofilament light chain with urinary albumin excretion in US adults: NHANES 2013-2014

• Published in: Renal failure 2024-12, Vol.46 (2), p.2391955
• Main Authors: Liu, Yanting, Yang, Qian, Zhang, Meiyun, Lin, Jingna
• Format: Article
• Language: English
• Subjects: Adult; Aged; albumin-to-creatinine ratio; Albuminuria - blood; Albuminuria - urine; Biomarkers - blood; Biomarkers - urine; Chronic Kidney Disease and Progression; Creatinine - blood; Creatinine - urine; Cross-Sectional Studies; Female; Humans; J-shaped curve; Linear Models; Male; Middle Aged; Neurofilament Proteins - blood; Neurofilament Proteins - urine; NHANES; Nutrition Surveys; Serum neurofilament light chain; United States
• ISSN: 1525-6049; 0886-022X; 1525-6049
• DOI: 10.1080/0886022X.2024.2391955

This study focuses on investigating the relationship between serum neurofilament light chain (sNfL) and urinary albumin-to-creatinine ratio (uACR) among American adults aged 25-75. An analysis was conducted on information gathered from 1741 individuals aged between 25 and 75 who participated in the National Health and Nutrition Examination Survey (NHANES) during the years 2013-2014. Generalized linear models were utilized, and restricted cubic spline (RCS) analysis was conducted to assess a non-linear relationship. Upon adjusting for multiple variables, a non-linear inverse J-shaped relationship was observed between sNfL and uACR. Compared with individuals in quartile 1 (Q1) of sNfL (2.8-8.3), those with quartile 4 (Q4) (≥19.1) had an adjusted for uACR of 51.57. The study found a J-shaped curve linking sNfL and uACR in American adults, with a turning point around log(sNfL) 2.928 pg/mL.