Susceptibility to SARS-CoV-2 and MERS-CoV in Beagle Dogs

The coronavirus disease 19 (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus 2 (SARS-CoV-2), has resulted in unprecedented challenges to healthcare worldwide. In particular, the anthroponotic transmission of human coronaviruses has become a common concern among pet ow...

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Bibliographic Details
Published in:Animals (Basel) 2023-02, Vol.13 (4), p.624
Main Authors: Lyoo, Kwang-Soo, Yeo, Yoon-Hwan, Lee, Sung-Geun, Yeom, Minjoo, Lee, Joo-Yeon, Kim, Kyung-Chang, Song, Daesub
Format: Article
Language:English
Subjects:
Body temperature
Body weight loss
Coronavirus infections
Coronaviruses
COVID-19
Dehydrogenase
dog
Dogs
Feces
Health aspects
L-Lactate dehydrogenase
Lactate dehydrogenase
Lactic acid
Lungs
MERS-CoV
Middle East respiratory syndrome
Pathogenicity
Pathogens
Pets
SARS-CoV-2
Secretions
Severe acute respiratory syndrome coronavirus 2
susceptibility
Viruses
Weight loss
Zoonoses
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Summary:The coronavirus disease 19 (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus 2 (SARS-CoV-2), has resulted in unprecedented challenges to healthcare worldwide. In particular, the anthroponotic transmission of human coronaviruses has become a common concern among pet owners. Here, we experimentally inoculated beagle dogs with SARS-CoV-2 or Middle East respiratory syndrome (MERS-CoV) to compare their susceptibility to and the pathogenicity of these viruses. The dogs in this study exhibited weight loss and increased body temperatures and shed the viruses in their nasal secretions, feces, and urine. Pathologic changes were observed in the lungs of the dogs inoculated with SARS-CoV-2 or MERS-CoV. Additionally, clinical characteristics of SARS-CoV-2, such as increased lactate dehydrogenase levels, were identified in the current study.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani13040624