Effects of a Combination of Polynucleotide and Hyaluronic Acid for Treating Osteoarthritis

Knee osteoarthritis (OA), an age-related degenerative disease characterized by severe pain and disability, is treated using polynucleotides (PNs) and hyaluronic acid (HA). The intra-articular (IA) injection of HA has been studied extensively in both animal models and in humans; however, the efficacy...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-02, Vol.25 (3), p.1714
Main Authors: Choi, Seung Hee, Kim, Hyun Chul, Jang, Seul Gi, Lee, Yeon Jae, Heo, Jun Young, Kweon, Gi Ryang, Ryu, Min Jeong
Format: Article
Language:English
Subjects:
Analysis
anterior cruciate ligament transection
Arthritis
Care and treatment
Cartilage
Disease
Enzymes
Hyaluronic acid
Inflammation
knee OA
medial meniscectomy
Molecular weight
Nonsteroidal anti-inflammatory drugs
Orthopedics
Osteoarthritis
Pain
polynucleotide
Tumor necrosis factor-TNF
Viscoelasticity
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Description
Summary:Knee osteoarthritis (OA), an age-related degenerative disease characterized by severe pain and disability, is treated using polynucleotides (PNs) and hyaluronic acid (HA). The intra-articular (IA) injection of HA has been studied extensively in both animal models and in humans; however, the efficacy and mechanisms of action remain unclear. In addition, there has been a paucity of research regarding the use of PN alone or in combination with HA in OA. To investigate the effect of the combined injection of PN and HA in vivo, pathological and behavioral changes were assessed in an OA model. Anterior cruciate ligament transection and medial meniscectomy were performed in Sprague-Dawley rats to create the OA animal model. The locomotor activity improved following PNHA injection, while the OARSI grade improved in the medial tibia and femur. In mild OA, TNFα levels decreased histologically in the PN, HA, and PNHA groups but only the PNHA group showed behavioral improvement in terms of distance. In conclusion, PNHA exhibited anti-inflammatory effects during OA progression and improved locomotor activity regardless of the OARSI grade.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25031714