Bacterial Pathogens and Evaluation of a Cut-Off for Defining Early and Late Neonatal Infection

Bacterial infections are an important cause of mortality and morbidity in newborns. The main risk factors include low birth weight and prematurity. The study identified the most common bacterial pathogens causing neonatal infections including their resistance to antibiotics in the Neonatal Departmen...

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Bibliographic Details
Published in:Antibiotics (Basel) 2021-03, Vol.10 (3), p.278
Main Authors: Kucova, Pavla, Kantor, Lumir, Fiserova, Katerina, Lasak, Jakub, Röderova, Magdalena, Kolar, Milan
Format: Article
Language:English
Subjects:
Age
Amoxicillin
Ampicillin
antibiotic therapy
Antibiotics
Bacteria
Bacterial diseases
Bacterial infections
Birth weight
Clavulanic acid
Drug resistance
E coli
Gentamicin
Gram-positive bacteria
infection
Infections
Listeria
Low-birth-weight
Microorganisms
Morbidity
Multidrug resistant organisms
Neonates
newborn
Pathogens
Pneumonia
Risk analysis
Risk factors
Sepsis
Staphylococcus infections
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Summary:Bacterial infections are an important cause of mortality and morbidity in newborns. The main risk factors include low birth weight and prematurity. The study identified the most common bacterial pathogens causing neonatal infections including their resistance to antibiotics in the Neonatal Department of the University Hospital Olomouc. Additionally, the cut-off for distinguishing early- from late-onset neonatal infections was assessed. The results of this study show that a cut-off value of 72 h after birth is more suitable. Only in case of early-onset infections arising within 72 h of birth, initial antibiotic therapy based on gentamicin with ampicillin or amoxicillin/clavulanic acid may be recommended. It has been established that with the 72-h cut-off, late-onset infections caused by bacteria more resistant to antibiotics may be detected more frequently, a finding that is absolutely crucial for antibiotic treatment strategy.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics10030278