Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases

Curcumin is one of the most valuable natural products due to its pharmacological activities. However, the low bioavailability of curcumin has long been a problem for its medicinal use. Large studies have been conducted to improve the use of curcumin; among these studies, curcumin metabolites have be...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-12, Vol.22 (1), p.212
Main Authors: Kao, Yu-Wen, Hsu, Sheng-Kai, Chen, Jeff Yi-Fu, Lin, I-Ling, Chen, Kuo-Jen, Lee, Po-Yen, Ng, Hui-Suan, Chiu, Chien-Chih, Cheng, Kai-Chun
Format: Article
Language:English
Subjects:
Antiangiogenics
Antioxidants
Bioavailability
Biological activity
Cataracts
COX
Curcumin
Diabetes mellitus
Eye diseases
Glaucoma
Health services
Inflammatory diseases
Lipids
Macular degeneration
Medical research
Metabolism
Metabolites
Nanocrystals
Nanoemulsions
Nanoparticles
Natural products
Neuroprotection
ophthalmic diseases
Particle size
Pharmaceuticals
Plasma
Polyethylene glycol
Public health
Retinopathy
Review
SIRT1
tetrahydrocurcumin (THC)
Tumors
VEGF
Visual impairment
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Summary:Curcumin is one of the most valuable natural products due to its pharmacological activities. However, the low bioavailability of curcumin has long been a problem for its medicinal use. Large studies have been conducted to improve the use of curcumin; among these studies, curcumin metabolites have become a relatively new research focus over the past few years. Additionally, accumulating evidence suggests that curcumin or curcuminoid metabolites have similar or better biological activity than the precursor of curcumin. Recent studies focus on the protective role of plasma tetrahydrocurcumin (THC), a main metabolite of curcumin, against tumors and chronic inflammatory diseases. Nevertheless, studies of THC in eye diseases have not yet been conducted. Since ophthalmic conditions play a crucial role in worldwide public health, the prevention and treatment of ophthalmic diseases are of great concern. Therefore, the present study investigated the antioxidative, anti-inflammatory, antiangiogenic, and neuroprotective effects of THC on four major ocular diseases: age-related cataracts, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). While this study aimed to show curcumin as a promising potential solution for eye conditions and discusses the involved mechanistic pathways, further work is required for the clinical application of curcumin.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22010212