Increased Expression of Interleukin 18 mRNA is Associated with Carotid Artery Stenosis

Carotid artery stenosis (CAS) is the atherosclerotic narrowing of the proximal internal carotid artery (ICA) and one of the main causes of stroke. Elevated expression of the pleiotropic proinflammatory cytokine, interleukin-18 (IL18), has been shown in human atherosclerotic plaques. To investigate w...

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Bibliographic Details
Published in:Balkan medical journal 2018-05, Vol.35 (3), p.250-255
Main Authors: Arapi, Berk, Bayoğlu, Burcu, Cengiz, Müjgan, Dirican, Ahmet, Deser, Serkan Burç, Junusbekov, Yerik, Arslan, Caner
Format: Article
Language:English
Subjects:
Atherosclerosis
Cardiovascular disease
Carotid arteries
Carotid artery
Carotid artery diseases
Cytokines
Development and progression
Diabetes
Gene expression
Heart surgery
Interleukin-18
interleukin-18-binding protein
Medical imaging
Medicine
Messenger RNA
Original
Polymerase chain reaction
Polymorphism
stenosis
Stroke
Tıp
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Summary:Carotid artery stenosis (CAS) is the atherosclerotic narrowing of the proximal internal carotid artery (ICA) and one of the main causes of stroke. Elevated expression of the pleiotropic proinflammatory cytokine, interleukin-18 (IL18), has been shown in human atherosclerotic plaques. To investigate whether IL18 and interleukin-18 binding protein (IL18BP) mRNA expression and IL18 -137 G/C (rs187238) variants are associated with CAS development. Case-control study. IL18 and IL18BP mRNA expression and IL18 rs187238 variants were evaluated by quantitative real-time polymerase chain reaction (RT-qPCR) and real-time PCR, respectively, in peripheral blood mononuclear cells (PBMCs) of 70 patients with CAS (36 symptomatic, 34 asymptomatic) and 75 healthy controls. IL18 mRNA expression was significantly increased in CAS patients compared to healthy controls (p=0.01). However, there was no significant difference between IL18BP mRNA levels in patients with CAS and controls (p=0.101). ICA stenosis severity was higher in symptomatic patients than in asymptomatic patients (p
ISSN:2146-3123
2146-3131
DOI:10.4274/balkanmedj.2017.0323