Mechanistic validation of the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging Guidelines for the assessment of diastolic dysfunction in heart failure with reduced ejection fraction

Background The American Society for Echocardiography/European Association of Cardiovascular Imaging (ASE/EACVI) 2016 guidelines for assessment of diastolic dysfunction (DD) are based primarily on the effects of diastolic dysfunction on left ventricular filling hemodynamics. However, these measures d...

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Bibliographic Details
Published in:Cardiovascular ultrasound 2020-10, Vol.18 (1), p.1-42, Article 42
Main Authors: Goldberg, Ythan H., Megyessi, David, Flam, Mischa, Spevack, Daniel M., Sundqvist, Martin G., Ugander, Martin
Format: Article
Language:English
Subjects:
Blood flow
Congestive heart failure
Diastolic function
Echocardiography
Ejection fraction
Formalism
Guidelines
Heart failure
Heart rate
Hemodynamics
Kinematics
Mechanical properties
Medicin och hälsovetenskap
Patients
Physical properties
Pulsed-wave Doppler
Quality
Software
Statistical analysis
Stiffness
Transthoracic echocardiography
Velocity
Ventricle
Viscoelasticity
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Summary:Background The American Society for Echocardiography/European Association of Cardiovascular Imaging (ASE/EACVI) 2016 guidelines for assessment of diastolic dysfunction (DD) are based primarily on the effects of diastolic dysfunction on left ventricular filling hemodynamics. However, these measures do not provide quantifiable mechanistic information about diastolic function. The Parameterized Diastolic Filling (PDF) formalism is a validated theoretical framework that describes DD in terms of the physical properties of left ventricular filling. Aims We hypothesized that PDF analysis can provide mechanistic insight into the mechanical properties governing higher grade DD. Methods Patients referred for echocardiography showing reduced left ventricular ejection fraction (
ISSN:1476-7120
1476-7120
DOI:10.1186/s12947-020-00224-z