Physical frailty, genetic predisposition, and incident dementia: a large prospective cohort study

Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical frailty, genetic risk, and dementia incidence. A total of 274,194 participants from the UK B...

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Bibliographic Details
Published in:Translational psychiatry 2024-05, Vol.14 (1), p.212-212, Article 212
Main Authors: Gao, Pei-Yang, Ma, Ling-Zhi, Wang, Xue-Jie, Wu, Bang-Sheng, Huang, Yi-Ming, Wang, Zhi-Bo, Fu, Yan, Ou, Ya-Nan, Feng, Jian-Feng, Cheng, Wei, Tan, Lan, Yu, Jin-Tai
Format: Article
Language:English
Subjects:
631/378
692/699
Aged
Behavioral Sciences
Biological Psychology
Dementia
Dementia - epidemiology
Dementia - genetics
Female
Frailty
Frailty - epidemiology
Frailty - genetics
Genetic Predisposition to Disease
Humans
Incidence
Male
Medicine
Medicine & Public Health
Middle Aged
Neurosciences
Pharmacotherapy
Proportional Hazards Models
Prospective Studies
Psychiatry
Risk Factors
United Kingdom - epidemiology
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Summary:Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical frailty, genetic risk, and dementia incidence. A total of 274,194 participants from the UK Biobank were included. We applied Cox proportional hazards regression models to estimate the association between physical frailty and genetic and dementia risks. Among the participants (146,574 females [53.45%]; mean age, 57.24 years), 3,353 (1.22%) new-onset dementia events were recorded. Compared to non-frailty, the hazard ratio (HR) for dementia incidence in prefrailty and frailty was 1.396 (95% confidence interval [CI], 1.294–1.506, P  
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-024-02927-7