Enlarged airspaces in the distal lung in adolescents born very preterm as measured by aerosol

RationalePreterm infants diagnosed with bronchopulmonary dysplasia (BPD) are thought to have fewer and larger alveoli than their term peers, but it is unclear to what degree this persists later in life.ObjectivesTo investigate to what degree the distal airspaces are enlarged in adolescents born pret...

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Bibliographic Details
Published in:BMJ open respiratory research 2024-12, Vol.11 (1), p.e002666
Main Authors: Öhrneman, Hugo, Lindström, Frida, Hagman, Cecilia, Petersson Sjögren, Madeleine, Rissler, Jenny, Wollmer, Per, Tufvesson, Ellen, Löndahl, Jakob
Format: Article
Language:English
Subjects:
Aerosols
Airway management
Asthma
Autopsies
Birth weight
Carbon monoxide
Continuous positive airway pressure
Emphysema
Gestational age
Lung diseases
Lungs
Original Research
Paediatric Lung Disaese
Patients
Premature birth
Radiation
Respiratory Measurement
Respiratory Research
Spirometry
Standard scores
Teenagers
Ventilators
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Summary:RationalePreterm infants diagnosed with bronchopulmonary dysplasia (BPD) are thought to have fewer and larger alveoli than their term peers, but it is unclear to what degree this persists later in life.ObjectivesTo investigate to what degree the distal airspaces are enlarged in adolescents born preterm and to evaluate the new Airspace Dimension Assessment (AiDA) method in investigating this group.MethodsWe investigated 41 adolescents between 15 and 17 years of age, of whom 25 were born very preterm (a gestational age
ISSN:2052-4439
DOI:10.1136/bmjresp-2024-002666