Impact of Chronic Hepatitis C Virus Genotype 1b Infection on Triglyceride Concentration in Serum Lipoprotein Fractions

Reduced low-density lipoprotein (LDL) cholesterol level is a characteristic feature of dyslipidemia in chronic hepatitis C virus (HCV) infection. However, abnormality in serum triglyceride (TG) has not been fully investigated. To clarify the impact of HCV genotype 1b (G1b) infection and advanced fib...

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Bibliographic Details
Published in:International journal of molecular sciences 2015-08, Vol.16 (9), p.20576-20594
Main Authors: Nagano, Tomohisa, Seki, Nobuyoshi, Tomita, Yoichi, Sugita, Tomonori, Aida, Yuta, Itagaki, Munenori, Sutoh, Satoshi, Abe, Hiroshi, Tsubota, Akihito, Aizawa, Yoshio
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Biomarkers
chronic hepatitis C (CHC)
Female
Genotype
Genotype & phenotype
Hepacivirus - genetics
Hepatitis
Hepatitis C virus
hepatitis C virus (HCV)
Hepatitis C, Chronic - blood
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - virology
Humans
lipoprotein
Lipoproteins
Lipoproteins - blood
Lipoproteins, VLDL
Liver Cirrhosis - blood
Liver Cirrhosis - etiology
Liver Cirrhosis - pathology
Male
Treatment Outcome
triglyceride (TG)
Triglycerides - blood
very-low-density lipoprotein (VLDL)
Viruses
VLDL sub-fractions
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Summary:Reduced low-density lipoprotein (LDL) cholesterol level is a characteristic feature of dyslipidemia in chronic hepatitis C virus (HCV) infection. However, abnormality in serum triglyceride (TG) has not been fully investigated. To clarify the impact of HCV genotype 1b (G1b) infection and advanced fibrosis on serum TG profiles, TG concentrations in lipoprotein fractions were examined in fasting sera from 185 subjects with active or cleared HCV infection by high-performance liquid chromatography. Serum lipoproteins were fractionated into four classes: chylomicron, very low-density lipoprotein (VLDL), LDL, and high-density lipoprotein (HDL). Then, the significance of HCV G1b infection on TG levels in each lipoprotein fraction was determined using multiple regression models. We found that active HCV G1b infection was positively associated with high HDL-TG levels and low VLDL-TG levels, independent of other factors included in the regression model. In VLDL sub-fractions, active HCV infection was only found to be associated with low levels of large VLDL-TG. Similarly, advanced liver fibrosis in chronic HCV G1b infection was associated with high levels of LDL-TG, HDL-TG, and small VLDL-TG, independent of other clinical factors. These findings indicate that active HCV G1b infection and advanced fibrosis are closely associated with abnormal serum TG profiles.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms160920576