MSCs from polytrauma patients: preliminary comparative study with MSCs from elective-surgery patients

Background Polytrauma is a major clinical problem due to its impact on morbidity and mortality, especially among the younger population. Its pathophysiology is not completely elucidated, and the study of the involvement of certain cell populations with therapeutic potential, such as mesenchymal stro...

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Published in:Stem cell research & therapy 2021-08, Vol.12 (1), p.1-451, Article 451
Main Authors: López, Raúl, Martí-Chillón, Gerardo J, Blanco, Juan F, da Casa, Carmen, González-Robledo, Javier, Pescador, David, Preciado, Silvia, Muntión, Sandra, Sánchez-Guijo, Fermín
Format: Article
Language:English
Subjects:
Back surgery
Bone marrow
Bone regeneration
CD105 antigen
Cell adhesion molecules
Cell cycle
Cell differentiation
Cellular therapy
Comparative analysis
Cytokines
Flow cytometry
Gene expression
Health aspects
Hospital patients
Immunoregulation
Inflammation
Injuries
Intensive care
Medical research
Medicine, Experimental
Mesenchymal stem cells
Mesenchymal stromal cells
Mesenchyme
Morbidity
Morphology
Mortality
MSC
Patients
Polytrauma
Stem cells
Stromal cells
Surgery
Transplantation
Trauma
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Summary:Background Polytrauma is a major clinical problem due to its impact on morbidity and mortality, especially among the younger population. Its pathophysiology is not completely elucidated, and the study of the involvement of certain cell populations with therapeutic potential, such as mesenchymal stromal cells (MSCs), is an area of growing interest, as mesenchymal cells have anti-inflammatory, immunoregulatory, and osteogenic potential. Methods In the present preliminary work, we have evaluated the characteristics of MSCs in terms of proliferation, immunophenotype, cell cycle, clonogenic capacity, and multilineage differentiation ability in a series of 18 patients with polytrauma and compared them to those from otherwise healthy patients undergoing elective spinal surgery. Results MSCs from polytrauma patients displayed higher proliferative potential with significantly higher cumulative population doublings, increased expression of some important cell adhesion molecules (CD105, CD166), and an early pre-osteogenic differentiation ability compared to those of the control group. Conclusions MSCs could potentially be of help in the repair process of polytrauma patients contribute to both cell-tissue repair and anti-inflammatory response. This potential should be further explored in larger studies. Keywords: Polytrauma, Bone regeneration, Mesenchymal stromal cells, Mesenchymal stem cells, MSC, Cellular therapy
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-021-02500-9