Dietary benzoic acid supplementation attenuates enterotoxigenic Escherichia coli K88-induced inflammation response and intestinal barrier dysfunction associated with gut microbiota modulation in newly-weaned mice

[Display omitted] •Benzoic acid alleviated ETEC K88-induced gut barrier dysfunction in weaned mice.•Benzoic acid reduced ETEC K88-induced inflammation response in weaned mice.•Benzoic acid restored ETEC K88-induced gut microbiota disruption in weaned mice. This study aimed to investigate the impact...

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Bibliographic Details
Published in:Journal of functional foods 2024-02, Vol.113, p.106044, Article 106044
Main Authors: Chen, Jun, Chen, Jinyong, Jia, Xuena, Hu, Youjun, Zhao, Xiaonan, You, Jinming, Zou, Tiande
Format: Article
Language:English
Subjects:
Benzoic acid
colon
enterotoxigenic Escherichia coli
Erysipelotrichaceae
ETEC K88
Gut microbiota
inflammation
Inflammation response
Intestinal barrier dysfunction
intestinal microorganisms
Newly-weaned mice
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Summary:[Display omitted] •Benzoic acid alleviated ETEC K88-induced gut barrier dysfunction in weaned mice.•Benzoic acid reduced ETEC K88-induced inflammation response in weaned mice.•Benzoic acid restored ETEC K88-induced gut microbiota disruption in weaned mice. This study aimed to investigate the impact of benzoic acid (BA) on inflammation response, intestinal barrier dysfunction, and gut microbiota in newly-weaned mice infected with enterotoxigenic Escherichia coli K88 (ETEC K88). A sum of thirty newly-weaned BALB/c mice were assigned to five groups, including the non-ETEC K88 infection group and the ETEC K88 infection + BA groups (0 %, 0.4 %, 0.6 %, and 0.8 % BA). The addition of 0.6 % BA mitigated inflammatory response and intestinal barrier impairment caused by ETEC K88. The supplementation of 0.6 % BA resulted in an increase in the Observed_species, as well as the relative abundance of Erysipelotrichaceae and Faecalibacterium in the colon microbiota of mice. Spearman’s correlations analysis indicated a strong association between gut microbiota and parameters related to inflammation response and intestinal barrier function. Collectively, dietary 0.6 % BA supplementation could attenuate ETEC K88-induced inflammation response and intestinal barrier dysfunction associated with gut microbiota modulation in newly-weaned mice.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2024.106044