Association of neutrophils, monocytes, and lymphocytes with CA15-3 as a predictor of breast cancer in female patients

Infiltrated leukocytes, such as neutrophils, monocytes and lymphocytes can be involved in a variety of tumor development. The present study was aimed to investigate the linkage of neutrophils, monocytes and lymphocytes into breast cancer. The study included 166 patients (58 patients before chemother...

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Published in:Journal of advanced biotechnology and experimental therapeutics 2024-03, Vol.7 (2), p.433-441
Main Authors: Madhi, Raed, Jumaah, Hussein, Hasan, Hasan
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Language:English
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breast cancer
ca15-3
grades
lymphocytes
monocytes
neutrophil
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Jumaah, Hussein
Hasan, Hasan
description Infiltrated leukocytes, such as neutrophils, monocytes and lymphocytes can be involved in a variety of tumor development. The present study was aimed to investigate the linkage of neutrophils, monocytes and lymphocytes into breast cancer. The study included 166 patients (58 patients before chemotherapy and 58 patients after chemotherapy. CA15-3 antigen levels were measured and grading of breast cancer were identified. In addition, neutrophils, monocytes and lymphocytes percentage and their correlation into CA15-3 antigen were determined. The results observed a significant increase (P
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Additionally, the results showed a positive correlation between neutrophil and monocytes percentage with CA15-3 antigen levels before and after treatment. However, the correlation was negative between lymphocytes percentage and CA15-3 antigen levels. The present findings observed that neutrophils and monocytes have a great association with CA-15-3 antigen levels, a marker of breast cancer, therefore, targeting these cells could protect against breast cancer development. However, targeting these cells can negatively affect the patient immune response, thus further studies are needed to study that exact mechanism by which neutrophils and monocytes could enhance breast cancer development. 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Additionally, the results showed a positive correlation between neutrophil and monocytes percentage with CA15-3 antigen levels before and after treatment. However, the correlation was negative between lymphocytes percentage and CA15-3 antigen levels. The present findings observed that neutrophils and monocytes have a great association with CA-15-3 antigen levels, a marker of breast cancer, therefore, targeting these cells could protect against breast cancer development. However, targeting these cells can negatively affect the patient immune response, thus further studies are needed to study that exact mechanism by which neutrophils and monocytes could enhance breast cancer development. 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subjects breast cancer
ca15-3
grades
lymphocytes
monocytes
neutrophil
title Association of neutrophils, monocytes, and lymphocytes with CA15-3 as a predictor of breast cancer in female patients
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