Different visual evoked potentials in neuromyelitis optica spectrum disorder-related optic neuritis and idiopathic demyelinating optic neuritis: a prospective longitudinal analysis

Background To investigate different visual evoked potential (VEP) patterns in neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON) and idiopathic demyelinating optic neuritis (IDON). Methods This was a longitudinal, prospective, case-control study. Eighty-four Chinese patients wi...

Full description

Saved in:
Bibliographic Details
Published in:BMC ophthalmology 2022-09, Vol.22 (1), p.1-376, Article 376
Main Authors: Zheng, Cong, Wang, Ling, Xu, Xiaoyu, Zhou, Manli, Liu, Kaiqun, Zhang, Yuxin, Zhao, Xiujuan, Lu, Lin, Qiu, Wei, Zhang, Xinyu, Yang, Hui
Format: Article
Language:English
Subjects:
Acuity
Antibodies
Antigens
Demyelination
Idiopathic demyelinating optic neuritis
Latency
Magnetic resonance imaging
Medical records
Medical research
Medicine, Experimental
Neuritis
Neuromyelitis
Neuromyelitis optica
Neuromyelitis optica spectrum disorder
Optic neuritis
Values
Visual evoked potential
Visual evoked potentials
Visual pathways
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background To investigate different visual evoked potential (VEP) patterns in neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON) and idiopathic demyelinating optic neuritis (IDON). Methods This was a longitudinal, prospective, case-control study. Eighty-four Chinese patients with acute optic neuritis were enrolled, including 26 NMOSD-ON patients and 58 IDON patients. All the patients underwent best-corrected visual acuity (BCVA) and full-field pattern reversal VEP recordings at the onset, 1 month, 3 months, and 6 months. Results Within 15' checks, the NMOSD-ON patients had more severe VEP amplitude reduction at 6 months (2.39 [+ or -] 4.63 [mu]V vs. 6.96 [+ or -] 8.88 [mu]V, P = 0.034). However, the IDON patients showed more frequently normal VEP response at 3 months (24.0% vs. 4.5%, P = 0.017), and only prolonged P100 peak latency with normal amplitude (L) at 6 months (30.0% vs. 57.8%, P = 0.048). Within 60' checks, no significant difference in VEP parameters between the two groups was found at each follow-up (P > 0.05). Conclusions The NMOSD-ON patients showed more severe axonal damage and worse axonal recovery than the IDON patients. VEP elicited by smaller check size was more sensitive to visual pathway abnormality in NMOSD-ON. Keywords: Neuromyelitis optica spectrum disorder, Idiopathic demyelinating optic neuritis, Visual evoked potential
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-022-02595-5