Ketamine–propofol sedation in circumcision

• Published in: Brazilian journal of anesthesiology (Elsevier) 2015-09, Vol.65 (5), p.367-370
• Main Authors: Gulec, Handan, Sahin, Saziye, Ozayar, Esra, Degerli, Semih, Bercin, Fatma, Ozdemir, Osman
• Format: Article
• Language: English
• Subjects: ANESTHESIOLOGY; Cetamina-propofol; Child; Child, Preschool; Circumcision; Circumcision, Male; Circuncisão; Conscious Sedation - adverse effects; Double-Blind Method; Drug Combinations; Hemodynamics - drug effects; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - pharmacology; Ketamine - administration & dosage; Ketamine - pharmacology; Ketamine–propofol; Male; Propofol - administration & dosage; Propofol - pharmacology; Sedation; Sedação
• ISSN: 0104-0014; 1806-907X; 0104-0014
• DOI: 10.1016/j.bjane.2014.03.002

To compare the therapeutic effects of ketamine alone or ketamine plus propofol on analgesia, sedation, recovery time, side effects in premedicated children with midazolam–ketamine–atropin who are prepared circumcision operation. 60 American Society of Anaesthesiologists physical status I–II children, aged between 3 and 9 years, undergoing circumcision operations under sedation were recruited according to a randomize and double-blind institutional review board-approved protocol. Patients were randomized into two groups via sealed envelope assignment. Both groups were administered a mixture of midazolam 0.05mg/kg+ketamine 3mg/kg+atropine 0.02mg/kg intramuscularly in the presence of parents in the pre-operative holding area. Patients were induced with propofol–ketamine in Group I or ketamine alone in Group II. In the between-group comparisons, age, weight, initial systolic blood pressure, a difference in terms of the initial pulse rate was observed (p>0.050). Initial diastolic blood pressure and subsequent serial measurements of 5, 10, 15, 20thmin, systolic blood pressure, diastolic blood pressure and pulse rate in ketamine group were significantly higher (p