Effectiveness of Reduced-fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

• Published in: Ophthalmology science (Online) 2022-06, Vol.2 (2), p.100152, Article 100152
• Main Authors: Aisu, Nao, Miyake, Masahiro, Hosoda, Yoshikatsu, Mori, Yuki, Takahashi, Ayako, Muraoka, Yuki, Ueda-Arakawa, Naoko, Miyata, Manabu, Oishi, Akio, Tamura, Hiroshi, Ooto, Sotaro, Yamashiro, Kenji, Tsujikawa, Akitaka
• Format: Article
• Language: English
• Subjects: Central serous chorioretinopathy; Propensity score; Reduced-fluence photodynamic therapy; Serous retinal detachment
• ISSN: 2666-9145; 2666-9145
• DOI: 10.1016/j.xops.2022.100152

To investigate the 2-year effectiveness of reduced-fluence photodynamic therapy (rf-PDT) for chronic central serous chorioretinopathy (cCSC). Retrospective cohort study. A total of 223 consecutive patients with newly diagnosed cCSC with active serous retinal detachment (SRD) were included from May 2007 to June 2017 and followed up for at least 2 years. Patients who underwent ocular treatment other than cataract surgery before the beginning of recruitment and those who had macular neovascularization at baseline were excluded. All patients underwent a comprehensive ophthalmic evaluation, including measurements of best-corrected visual acuity (BCVA), slit-lamp examination, dilated fundus examination, color fundus photography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, and spectral-domain OCT. An inverse probability of treatment weighting (IPTW) methodology was applied to balance 18 baseline characteristics between patients who received rf-PDT (rf-PDT group) and those who did not receive treatment (controls). Inverse probability of treatment weighting survival analysis and regression were performed. The proportion of patients whose BCVA at 24 months was the same or improved compared with the baseline visual acuity (VA) (VA maintenance rate). A total of 155 eyes (rf-PDT group: 74; controls: 81) were analyzed. The patients’ backgrounds were well balanced after IPTW with standardized differences of < 0.10. An IPTW regression analysis revealed that the VA maintenance rate was significantly higher in the rf-PDT group than in the controls (93.6% vs. 70.9%, P