Pseudomonas aeruginosa : Infections, Animal Modeling, and Therapeutics

is an important Gram-negative opportunistic pathogen which causes many severe acute and chronic infections with high morbidity, and mortality rates as high as 40%. What makes a particularly challenging pathogen is its high intrinsic and acquired resistance to many of the available antibiotics. In th...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2023-01, Vol.12 (1), p.199
Main Authors: Wood, Stephen J, Kuzel, Timothy M, Shafikhani, Sasha H
Format: Article
Language:English
Subjects:
acute infections
Animal models
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
antibiotic resistance
Antibiotics
chronic infections
Contact lenses
Cornea
cystic fibrosis (CF)
Cystic Fibrosis - drug therapy
Drug resistance
Hospitals
infection
Models, Animal
Morbidity
Opportunist infection
Pathogens
Persistent Infection
Pneumonia
Pseudomonas aeruginosa
Pseudomonas Infections - drug therapy
Respiration
Review
Reviews
Staphylococcus infections
Ulcers
Urinary tract infections
Urogenital system
Ventilators
Virulence
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Description
Summary:is an important Gram-negative opportunistic pathogen which causes many severe acute and chronic infections with high morbidity, and mortality rates as high as 40%. What makes a particularly challenging pathogen is its high intrinsic and acquired resistance to many of the available antibiotics. In this review, we review the important acute and chronic infections caused by this pathogen. We next discuss various animal models which have been developed to evaluate pathogenesis and assess therapeutics against this pathogen. Next, we review current treatments (antibiotics and vaccines) and provide an overview of their efficacies and their limitations. Finally, we highlight exciting literature on novel antibiotic-free strategies to control infections.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells12010199