Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice

Background. Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. Methods. We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. Resul...

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Bibliographic Details
Published in:Journal of immunology research 2014-01, Vol.2014 (2014), p.1-13
Main Authors: Pan, Xing-hua, Pang, Rong-qing, Li, Zi-an, Shu, Fan, Wang, Jin-xiang, Yang, Shuang-juan, Yao, Xiang, Ruan, Guang-ping, Liu, Ju-fen
Format: Article
Language:English
Subjects:
Animals
Antibodies, Antinuclear - blood
Bone marrow
CD4 Antigens - metabolism
DNA - immunology
Forkhead Transcription Factors - metabolism
Histones - immunology
Humans
Immune system
Immunology
Interleukin-2 Receptor alpha Subunit - metabolism
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - therapy
Lymphocyte Count
Mesenchymal Stem Cell Transplantation
Mesenchymal Stromal Cells - physiology
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Stem cells
T-Lymphocytes, Regulatory - immunology
Transplantation, Heterologous
Transplants & implants
Umbilical Cord - cytology
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Summary:Background. Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. Methods. We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. Results. After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4+CD25+Foxp3+ T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation. Conclusions. The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.
ISSN:2314-8861
2314-7156
DOI:10.1155/2014/530501