Immune-enhancing effect of fermented soybean food, Cheonggukjang on cyclophosphamide-treated immunosuppressed rat

Cheonggukjang (CGJ) is a traditional food, made by the fermentation of beans, and it has different recipes for different regions in Korea. However, it has anti-inflammatory, anti-cancer, and anti-obesity effects, and is known to affect changes in the intestinal microbiota. In this study, we investig...

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Published in:Heliyon 2024-09, Vol.10 (18), p.e37845, Article e37845
Main Authors: Lee, Hak Yong, Park, Young Mi, Shin, Dong Yeop, Hwang, Hai Min, Jeong, Han Na, Park, Hyo Yeon, Yang, Hee-Jong, Ha, Gwang Su, Ryu, Myeong Seon, Seo, Ji Won, Jeong, Do-Youn, Bae, Jun Sang, Kim, Byeong Soo, Kim, Jae Gon
Format: Article
Language:English
Subjects:
Bacteroidetes
blood serum
Cheonggukjang
cyclophosphamide
Cytokines
digestive system
fermentation
histology
Immune-enhancing
immunity
inflammation
Inflammatory pathways
intestinal microorganisms
Korean Peninsula
oral administration
rats
soybeans
Spleen
traditional foods
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Summary:Cheonggukjang (CGJ) is a traditional food, made by the fermentation of beans, and it has different recipes for different regions in Korea. However, it has anti-inflammatory, anti-cancer, and anti-obesity effects, and is known to affect changes in the intestinal microbiota. In this study, we investigated the immune-enhancing effects of four type CGJs (one commercial and three transitional CGJs). In the cyclophosphamide (CP)-treated immunosuppressed rat, oral administration of CGJs for 4 weeks was used to investigate weight of body and immune organ, change of microbiota, blood and serum parameters, inflammation pathways (MAPKs and NFκB) and histology of spleen. It showed an immunity-enhancing effect through increase Bacteroidetes in gut, the recovery of complete blood count, levels of cytokines and IgG, activation of inflammatory pathways, and histology of spleen. In conclusion, these results show that the intake of a commercial brand CGJ, and traditional CGJs can maintain or promote the body's immunity. [Display omitted] •Cheonggukjang regulate Firmicutes/Bacteroidetes ratio.•Cheonggukjang promotes the IL-2, IL-12, IFN-γ and IgG productions in immunosuppression status.•Cheonggukjang increases proliferation of splenocyte and NK cell activity.•Cheonggukjang activate MAPKs and NFκB pathways.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e37845