A Challenging Diagnosis: Placental Mesenchymal Dysplasia-Literature Review and Case Report

We describe a 22-year-old woman (2-gravid) case who was referred to our clinic at 18 weeks of gestation for a placenta with vesicular lesions discovered on prenatal examination routine. An ultrasound exam at 31 weeks of gestation showed numerous vesicular lesions, which gradually augmented as the pr...

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Bibliographic Details
Published in:Diagnostics (Basel) 2022-01, Vol.12 (2), p.293
Main Authors: Mehedintu, Claudia, Frincu, Francesca, Ionescu, Oana-Maria, Cirstoiu, Monica Mihaela, Sajin, Maria, Olinca, Maria, Bratila, Elvira, Petca, Aida, Carp-Veliscu, Andreea
Format: Article
Language:English
Subjects:
Abortion
alpha-fetoprotein
Amniotic fluid
Anemia
Babies
Case reports
Cysts
Enzymes
Fetuses
Hyperplasia
molar pregnancy
Morphology
Placenta
placental mesenchymal dysplasia
Preeclampsia
Pregnancy
Review
Ultrasonic imaging
β-human chorionic gonadotropin
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Summary:We describe a 22-year-old woman (2-gravid) case who was referred to our clinic at 18 weeks of gestation for a placenta with vesicular lesions discovered on prenatal examination routine. An ultrasound exam at 31 weeks of gestation showed numerous vesicular lesions, which gradually augmented as the pregnancy advanced. A live normal-appearing fetus was confirmed by intrauterine growth restriction (IUGR). The maternal serum β-human chorionic gonadotropin level remained in normal ranges. At some point, a multidisciplinary medical consensus considered the termination of the pregnancy, but the patient refused to comply. At 33 weeks of gestation, preterm premature rupture of membranes (pPROM) occurred, and she spontaneously delivered a 1600 g healthy female baby with a good long-term outcome. Placental mesenchymal dysplasia (PMD) was retrospectively diagnosed after confronting the data from ultrasound, chorionic villus sampling (CVS), amniocentesis, pathological examination, and immunohistochemical stain. The lack of sufficient reports of PMD determines doctors to be cautious and reserved, approaching these cases more radically than necessary. We reviewed this disease and searched for all cases of PMD associated with healthy, live newborns.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12020293