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Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer
Oncogenic fusion gene Echinoderm Microtubule-associated protein-Like 4-Anaplastic Lymphoma Kinase (EML4-ALK) contributes to tumorigenesis of a subset of non-small cell lung cancer (NSCLC). Recently, we demonstrated that F-circEA-4a, a tumor-promoting circular RNA (circRNA) generated from the back-sp...
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| Published in: | Molecular cancer 2018-09, Vol.17 (1), p.138-138, Article 138 |
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| container_title | Molecular cancer |
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| creator | Tan, Shuangyan Sun, Dan Pu, Wenchen Gou, Qiheng Guo, Chenglin Gong, Youling Li, Jiao Wei, Yu-Quan Liu, Lunxu Zhao, Yun Peng, Yong |
| description | Oncogenic fusion gene Echinoderm Microtubule-associated protein-Like 4-Anaplastic Lymphoma Kinase (EML4-ALK) contributes to tumorigenesis of a subset of non-small cell lung cancer (NSCLC). Recently, we demonstrated that F-circEA-4a, a tumor-promoting circular RNA (circRNA) generated from the back-splicing of EML4-ALK variant 3b (v3b), is a novel liquid biopsy biomarker for NSCLC. However, circRNAs produced from EML4-ALK gene and their roles in NSCLC are not well-characterized. Here, we identify another EML4-ALK-v3b-derived circRNA, F-circEA-2a, harboring "AA" (rather than "AAAA" in F-circEA-4a) motif at the junction site. F-circEA-2a mainly locates in the cytoplasm and promotes cell migration and invasion, but has little effect on cell proliferation. Moreover, F-circEA-2a exists in tumor, but not in the plasma of NSCLC patients with EML4-ALK fusion gene, further supporting the significant diagnostic value of F-circEA-4a for EML4-ALK-positive NSCLC. This work finds a novel oncogenic circRNA generated from EML4-ALK fusion gene, highlighting the pivotal role of circRNA in EML4-ALK-positive NSCLC development. |
| doi_str_mv | 10.1186/s12943-018-0887-9 |
| format | article |
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Recently, we demonstrated that F-circEA-4a, a tumor-promoting circular RNA (circRNA) generated from the back-splicing of EML4-ALK variant 3b (v3b), is a novel liquid biopsy biomarker for NSCLC. However, circRNAs produced from EML4-ALK gene and their roles in NSCLC are not well-characterized. Here, we identify another EML4-ALK-v3b-derived circRNA, F-circEA-2a, harboring "AA" (rather than "AAAA" in F-circEA-4a) motif at the junction site. F-circEA-2a mainly locates in the cytoplasm and promotes cell migration and invasion, but has little effect on cell proliferation. Moreover, F-circEA-2a exists in tumor, but not in the plasma of NSCLC patients with EML4-ALK fusion gene, further supporting the significant diagnostic value of F-circEA-4a for EML4-ALK-positive NSCLC. This work finds a novel oncogenic circRNA generated from EML4-ALK fusion gene, highlighting the pivotal role of circRNA in EML4-ALK-positive NSCLC development.</description><identifier>ISSN: 1476-4598</identifier><identifier>EISSN: 1476-4598</identifier><identifier>DOI: 10.1186/s12943-018-0887-9</identifier><identifier>PMID: 30236141</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>ALK protein ; Biomarkers ; Biopsy ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - pathology ; Care and treatment ; Cell adhesion & migration ; Cell fusion ; Cell growth ; Cell Line, Tumor ; Cell migration ; Cell migration/invasion ; Cell Movement - genetics ; Cell Proliferation ; Chromosome Breakpoints ; Circular RNA ; Cytoplasm ; Diagnosis ; EML4-ALK ; Fusion protein ; Genetic aspects ; Humans ; Kinases ; Laboratories ; Letter to the Editor ; Lung cancer ; Lung cancer, Non-small cell ; Lung Neoplasms - genetics ; Lung Neoplasms - pathology ; Lymphoma ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Oncogene Proteins, Fusion - genetics ; Patient outcomes ; Protein-tyrosine kinase ; Proteins ; Ribonucleic acid ; RNA ; RNA - genetics ; Sequence Analysis, DNA ; Splicing ; Thoracic surgery ; Tumorigenesis</subject><ispartof>Molecular cancer, 2018-09, Vol.17 (1), p.138-138, Article 138</ispartof><rights>COPYRIGHT 2018 BioMed Central Ltd.</rights><rights>Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-5f518078b4273fe0004cea85de9df1f41d900499f3b219f68fe4c58fcd9722b53</citedby><cites>FETCH-LOGICAL-c490t-5f518078b4273fe0004cea85de9df1f41d900499f3b219f68fe4c58fcd9722b53</cites><orcidid>0000-0002-1181-3467</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146612/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2122970917?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30236141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Shuangyan</creatorcontrib><creatorcontrib>Sun, Dan</creatorcontrib><creatorcontrib>Pu, Wenchen</creatorcontrib><creatorcontrib>Gou, Qiheng</creatorcontrib><creatorcontrib>Guo, Chenglin</creatorcontrib><creatorcontrib>Gong, Youling</creatorcontrib><creatorcontrib>Li, Jiao</creatorcontrib><creatorcontrib>Wei, Yu-Quan</creatorcontrib><creatorcontrib>Liu, Lunxu</creatorcontrib><creatorcontrib>Zhao, Yun</creatorcontrib><creatorcontrib>Peng, Yong</creatorcontrib><title>Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer</title><title>Molecular cancer</title><addtitle>Mol Cancer</addtitle><description>Oncogenic fusion gene Echinoderm Microtubule-associated protein-Like 4-Anaplastic Lymphoma Kinase (EML4-ALK) contributes to tumorigenesis of a subset of non-small cell lung cancer (NSCLC). Recently, we demonstrated that F-circEA-4a, a tumor-promoting circular RNA (circRNA) generated from the back-splicing of EML4-ALK variant 3b (v3b), is a novel liquid biopsy biomarker for NSCLC. However, circRNAs produced from EML4-ALK gene and their roles in NSCLC are not well-characterized. Here, we identify another EML4-ALK-v3b-derived circRNA, F-circEA-2a, harboring "AA" (rather than "AAAA" in F-circEA-4a) motif at the junction site. F-circEA-2a mainly locates in the cytoplasm and promotes cell migration and invasion, but has little effect on cell proliferation. Moreover, F-circEA-2a exists in tumor, but not in the plasma of NSCLC patients with EML4-ALK fusion gene, further supporting the significant diagnostic value of F-circEA-4a for EML4-ALK-positive NSCLC. This work finds a novel oncogenic circRNA generated from EML4-ALK fusion gene, highlighting the pivotal role of circRNA in EML4-ALK-positive NSCLC development.</description><subject>ALK protein</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Care and treatment</subject><subject>Cell adhesion & migration</subject><subject>Cell fusion</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell migration/invasion</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation</subject><subject>Chromosome Breakpoints</subject><subject>Circular RNA</subject><subject>Cytoplasm</subject><subject>Diagnosis</subject><subject>EML4-ALK</subject><subject>Fusion protein</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Letter to the Editor</subject><subject>Lung cancer</subject><subject>Lung cancer, Non-small cell</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymphoma</subject><subject>Non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>Patient outcomes</subject><subject>Protein-tyrosine kinase</subject><subject>Proteins</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Splicing</subject><subject>Thoracic surgery</subject><subject>Tumorigenesis</subject><issn>1476-4598</issn><issn>1476-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk2PFCEQhjtG437oD_BiSLzshZWvbuBiMpnMuhtHTYyeCU1Dy6QbRuiexIP_XWZmXXeMcACqnnpJVd6qeoXRNcaieZsxkYxChAVEQnAon1TnmPEGslqKp4_uZ9VFzhuEMBecPa_OKCK0wQyfV7-WPpl50Al8-bQAN9CU52oBiQadTX5nO-BSHMHq45rBxfoDcHP2MYDeBgu2JRMnm4GxwwBG3yc97ZM6dMCHnT6QPoAQA8yjLswBHObQA6ODselF9czpIduX9-dl9e1m9XV5C9ef398tF2tomEQTrF2NBeKiZYRTZxFCzFgt6s7KzmHHcCdLSEpHW4Kla4SzzNTCmU5yQtqaXlZ3R90u6o3aJj_q9FNF7dUhEFOvdJq8GaxCVGsjRGuwE8xKocvBKKbMNaallhetd0et7dyOtjM2TEkPJ6KnmeC_qz7uVBl402BSBK7uBVL8Mds8qdHn_WR0sHHOiuCyaoSIKOibf9BNnFMooyoUIZIjiflfqtelAR9cLP-avaha1DXnmFFCC3X9H6rszo7exGCdL_GTAnwsMCnmnKx76BEjtfefOvpPFf-pvf-ULDWvHw_noeKP4ehvtk_Tqg</recordid><startdate>20180920</startdate><enddate>20180920</enddate><creator>Tan, Shuangyan</creator><creator>Sun, Dan</creator><creator>Pu, Wenchen</creator><creator>Gou, Qiheng</creator><creator>Guo, Chenglin</creator><creator>Gong, Youling</creator><creator>Li, Jiao</creator><creator>Wei, Yu-Quan</creator><creator>Liu, Lunxu</creator><creator>Zhao, Yun</creator><creator>Peng, Yong</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1181-3467</orcidid></search><sort><creationdate>20180920</creationdate><title>Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer</title><author>Tan, Shuangyan ; Sun, Dan ; Pu, Wenchen ; Gou, Qiheng ; Guo, Chenglin ; Gong, Youling ; Li, Jiao ; Wei, Yu-Quan ; Liu, Lunxu ; Zhao, Yun ; Peng, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-5f518078b4273fe0004cea85de9df1f41d900499f3b219f68fe4c58fcd9722b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>ALK protein</topic><topic>Biomarkers</topic><topic>Biopsy</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Care and treatment</topic><topic>Cell adhesion & migration</topic><topic>Cell fusion</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell migration/invasion</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation</topic><topic>Chromosome Breakpoints</topic><topic>Circular RNA</topic><topic>Cytoplasm</topic><topic>Diagnosis</topic><topic>EML4-ALK</topic><topic>Fusion protein</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Letter to the Editor</topic><topic>Lung cancer</topic><topic>Lung cancer, Non-small cell</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymphoma</topic><topic>Non-small cell lung cancer</topic><topic>Non-small cell lung carcinoma</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>Patient outcomes</topic><topic>Protein-tyrosine kinase</topic><topic>Proteins</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecular cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Shuangyan</au><au>Sun, Dan</au><au>Pu, Wenchen</au><au>Gou, Qiheng</au><au>Guo, Chenglin</au><au>Gong, Youling</au><au>Li, Jiao</au><au>Wei, Yu-Quan</au><au>Liu, Lunxu</au><au>Zhao, Yun</au><au>Peng, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer</atitle><jtitle>Molecular cancer</jtitle><addtitle>Mol Cancer</addtitle><date>2018-09-20</date><risdate>2018</risdate><volume>17</volume><issue>1</issue><spage>138</spage><epage>138</epage><pages>138-138</pages><artnum>138</artnum><issn>1476-4598</issn><eissn>1476-4598</eissn><abstract>Oncogenic fusion gene Echinoderm Microtubule-associated protein-Like 4-Anaplastic Lymphoma Kinase (EML4-ALK) contributes to tumorigenesis of a subset of non-small cell lung cancer (NSCLC). Recently, we demonstrated that F-circEA-4a, a tumor-promoting circular RNA (circRNA) generated from the back-splicing of EML4-ALK variant 3b (v3b), is a novel liquid biopsy biomarker for NSCLC. However, circRNAs produced from EML4-ALK gene and their roles in NSCLC are not well-characterized. Here, we identify another EML4-ALK-v3b-derived circRNA, F-circEA-2a, harboring "AA" (rather than "AAAA" in F-circEA-4a) motif at the junction site. F-circEA-2a mainly locates in the cytoplasm and promotes cell migration and invasion, but has little effect on cell proliferation. Moreover, F-circEA-2a exists in tumor, but not in the plasma of NSCLC patients with EML4-ALK fusion gene, further supporting the significant diagnostic value of F-circEA-4a for EML4-ALK-positive NSCLC. This work finds a novel oncogenic circRNA generated from EML4-ALK fusion gene, highlighting the pivotal role of circRNA in EML4-ALK-positive NSCLC development.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>30236141</pmid><doi>10.1186/s12943-018-0887-9</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1181-3467</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | ALK protein Biomarkers Biopsy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Care and treatment Cell adhesion & migration Cell fusion Cell growth Cell Line, Tumor Cell migration Cell migration/invasion Cell Movement - genetics Cell Proliferation Chromosome Breakpoints Circular RNA Cytoplasm Diagnosis EML4-ALK Fusion protein Genetic aspects Humans Kinases Laboratories Letter to the Editor Lung cancer Lung cancer, Non-small cell Lung Neoplasms - genetics Lung Neoplasms - pathology Lymphoma Non-small cell lung cancer Non-small cell lung carcinoma Oncogene Proteins, Fusion - genetics Patient outcomes Protein-tyrosine kinase Proteins Ribonucleic acid RNA RNA - genetics Sequence Analysis, DNA Splicing Thoracic surgery Tumorigenesis |
| title | Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer |
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