Striatal increase of extracellular dopamine levels during dystonic episodes in a genetic model of paroxysmal dyskinesia

In vivo microdialysis was used to examine the levels of dopamine, serotonin, and their metabolites dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the striatum of dt sz mutant hamsters, an animal model of paroxysmal dyskinesia, in which stress...

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Bibliographic Details
Published in:Neurobiology of disease 2004-06, Vol.16 (1), p.78-84
Main Authors: Hamann, Melanie, Richter, Angelika
Format: Article
Language:English
Subjects:
Animals
Basal ganglia
Caudate putamen
Chorea - genetics
Chorea - metabolism
Corpus Striatum - metabolism
Cricetinae
Disease Models, Animal
Dopamine - biosynthesis
Dopamine - genetics
Dystonia
Dystonia - genetics
Dystonia - metabolism
Extracellular Fluid - metabolism
Female
Male
Mesocricetus
Microdialysis
Monoamines
Movement disorders
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Summary:In vivo microdialysis was used to examine the levels of dopamine, serotonin, and their metabolites dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the striatum of dt sz mutant hamsters, an animal model of paroxysmal dyskinesia, in which stress can precipitate dystonic episodes. Measurements were made under three different conditions in each animal: (1) at baseline in the absence of abnormal involuntary movements, (2) during an episode of paroxysmal dystonia precipitated by handling, and (3) during the recovery (postdystonic) period. In comparison to nondystonic control hamsters, which were treated in the same manner as dystonic animals, no changes could be detected under basal conditions, although the levels of DOPAC and HVA tended to be higher in mutant hamsters. Significantly elevated striatal levels of dopamine and DOPAC became evident during the period of stress-induced dystonic attacks in mutant hamsters. During dystonic episodes, dopamine levels were approximately 6.5-fold higher (followed by a 2.5-fold increase of DOPAC) in dt sz hamsters than in normal controls. Before the disappearance of dystonia, the levels of dopamine returned to basal concentrations in mutant hamsters. Consistent with previous pharmacologic findings, paroxysmal dystonia in mutant hamsters is associated with temporary increases of extracellular dopamine levels in the striatum.
ISSN:0969-9961
1095-953X
DOI:10.1016/j.nbd.2004.01.005