Successful treatment of Miescher's cheilitis in Melkersson-Rosenthal syndrome with betamethasone injections and doxycycline

We report a case of a 19-year-old girl who presented with 5-year history of swelling of upper lip and fissured tongue treated with dapsone then oral steroids without any improvement. Clinical examination found peripheral facial nerve paralysis and Labial mucosa biopsy showed non-necrotizing giganto-...

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Bibliographic Details
Published in:The Pan African medical journal 2012, Vol.13 (75), p.75-75
Main Authors: Oudrhiri, Lamia, Chiheb, Soumiya, Marnissi, Farida, Zamiati, Soumaya, Benchikhi, Hakima
Format: Article
Language:English
Subjects:
Betamethasone - administration & dosage
Betamethasone - therapeutic use
Case Report
Dapsone - therapeutic use
Doxycycline - administration & dosage
Doxycycline - therapeutic use
Drug Therapy, Combination
Female
Follow-Up Studies
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Humans
Injections, Intralesional
melkersson-rosenthal syndrome
Melkersson-Rosenthal Syndrome - diagnosis
Melkersson-Rosenthal Syndrome - drug therapy
Melkersson-Rosenthal Syndrome - pathology
miescher's cheilitis granulomatosa
treatment
Treatment Outcome
Young Adult
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Summary:We report a case of a 19-year-old girl who presented with 5-year history of swelling of upper lip and fissured tongue treated with dapsone then oral steroids without any improvement. Clinical examination found peripheral facial nerve paralysis and Labial mucosa biopsy showed non-necrotizing giganto-epithelioid granuloma. Diagnosis of Melkersson-Rosenthal syndrome was retaind because of association of cheilitis, lingua plicata and facial paralysis. Given the failure of dapsone and oral steroid we suggested an association of betamethasone injection and doxycycline. Gradual and permanent reduction of the upper lip volume was observed. One year follow up objectified no reactivation of cheilitis.
ISSN:1937-8688
1937-8688
DOI:10.11604/pamj.2012.13.75.1895