Cordyceps cicadae NTTU 868 Mycelium with The Addition of Bioavailable Forms of Magnesium from Deep Ocean Water Prevents the Aβ40 and Streptozotocin-Induced Memory Deficit via Suppressing Alzheimer’s Disease Risk Factors and Increasing Magnesium Uptake of Brain

Alzheimer’s disease (AD) is a common neurodegenerative disease characterized by continuous accumulation of β-amyloid (Aβ) in the brain. Deep ocean water (DOW) with rich inorganic salts and minerals was proven to promote fungi growth and metabolism. Cordyceps cicada, a functional food fungus, can pro...

Full description

Saved in:
Bibliographic Details
Published in:Fermentation (Basel) 2021, Vol.7 (1), p.39
Main Authors: Wu, Yan-Zhong, Lee, Chun-Lin
Format: Article
Language:English
Subjects:
Adenosine
Advanced glycosylation end products
Alzheimer's disease
Cordyceps
Cordyceps cicadae
deep ocean water
Disease
Experiments
Fermentation
Fungi
Inflammation
Magnesium
Microorganisms
Minerals
Monoclonal antibodies
N-(2-Hydroxyethyl) adenosine
Neurodegenerative diseases
Nutrients
Oxidants
polysaccharide
Polysaccharides
Proteins
Risk factors
Salts
Solvents
Streptozocin
β-Amyloid
β-Site APP-cleaving enzymes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Alzheimer’s disease (AD) is a common neurodegenerative disease characterized by continuous accumulation of β-amyloid (Aβ) in the brain. Deep ocean water (DOW) with rich inorganic salts and minerals was proven to promote fungi growth and metabolism. Cordyceps cicada, a functional food fungus, can produce higher anti-oxidant and anti-inflammatory compounds including adenosine, polysaccharide, and N(6)-(2-Hydroxyethyl) adenosine (HEA). This study used DOW as the culture water of C. cicadae NTTU 868 for producing DOW-cultured C. cicadae (DCC), and further investigated the effects and mechanisms on improving the memory deficit and repressing risk factors expressions in Aβ40 and streptozotocin (STZ)-induced Alzheimer’s disease rats model. In the results, DCC including mycelium and filtrate had adenosine, HEA, polysaccharide, and intracellular Mg2+ after fermentation with DOW. DCC had more effect on the improvement of memory deficit because it suppressed Aβ40 and streptozotocin (STZ) infusion caused BACE, pro-inflammatory factors expressions, and Aβ40 accumulation by increasing sRAGE expression in the brain. Furthermore, DCC enhanced the MAGT1 expression due to high organic magnesium, which can reverse Aβ40-induced cortex magnesium deficiency and further repress Aβ40 accumulation.
ISSN:2311-5637
2311-5637
DOI:10.3390/fermentation7010039